Fanconi Anemia Pathway in DNA repair

Stable Identifier
R-GGA-351465
Type
Pathway
Species
Gallus gallus
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Fanconi anemia (FA) is a rare human hereditary disorder characterized by bone marrow failure, compromised genomic stability and increased incidence of cancer, due to mutation in any of thirteen genes. The protein products of these genes are involved in DNA repair processes, though the roles for many of them remain to be defined. Three reactions that have been directly characterized in chicken cells, phosphorylation of FANCG, deubiquitination of FANCD2 (BRCA2), and the function of FANCJ (BRIP1) as a helicase, are annotated here.

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