Association of MRE11 with RAD50

Stable Identifier
Reaction [binding]
Gallus gallus
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MRE11 and RAD50 are homologs of proteins first identified in yeast by their effects on meiotic recombination (MRE11) and radiation sensitivity (RAD50). MRE11 and RAD50 form the catalytic core of the MRN complex; exonucleolytic and endonucleolytic activities are vested in MRE11; and DNA binding and ATPase activities are in RAD50. The MRE11-RAD50 complex is formed in the cytosol. Only upon subsequent interaction with NBS1 (forming the MRN complex), is the final complex recruited to the nucleus and to sites of DNA damage.

Literature References
PubMed ID Title Journal Year
15162012 Recombination repair pathway in the maintenance of chromosomal integrity against DNA interstrand crosslinks

Sasaki, MS, Takata, M, Sonoda, E, Tachibana, A, Takeda, S

Cytogenet Genome Res 2004
11062235 The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity

Tauchi, H, Kobayashi, J, Morishima, K, Matsuura, S, Nakamura, A, Shiraishi, T, Ito, E, Masnada, D, Delia, D, Komatsu, K

J Biol Chem 2001
15937485 The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions

Yabuki, M, Fujii, MM, Maizels, N

Nat Immunol 2005
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