Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
WNT3A [extracellular region]
Stable Identifier
R-GGA-3247784
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
extracellular region
Synonyms
N4GlycoAsn-PalmS WNT3A, Q2LMP1
Locations in the PathwayBrowser
Expand all
Developmental Biology (Gallus gallus)
MITF-M-regulated melanocyte development (Gallus gallus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Gallus gallus)
GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405 (Gallus gallus)
WNT3A [extracellular region] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by WNT (Gallus gallus)
TCF dependent signaling in response to WNT (Gallus gallus)
Canonical WNT signaling through the atypical receptor RYK (Gallus gallus)
RYK-binding WNTs [extracellular region] (Gallus gallus)
WNT3A [extracellular region] (Gallus gallus)
RYK:WNTs [plasma membrane] (Gallus gallus)
RYK-binding WNTs [extracellular region] (Gallus gallus)
WNT3A [extracellular region] (Gallus gallus)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Gallus gallus)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Gallus gallus)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Gallus gallus)
WNT:FZD:LRP5/6 [plasma membrane] (Gallus gallus)
canonical WNTs [extracellular region] (Gallus gallus)
WNT3A [extracellular region] (Gallus gallus)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Gallus gallus)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Gallus gallus)
WNT:FZD:LRP5/6 [plasma membrane] (Gallus gallus)
canonical WNTs [extracellular region] (Gallus gallus)
WNT3A [extracellular region] (Gallus gallus)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Gallus gallus)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Gallus gallus)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Gallus gallus)
WNT:FZD:LRP5/6 [plasma membrane] (Gallus gallus)
canonical WNTs [extracellular region] (Gallus gallus)
WNT3A [extracellular region] (Gallus gallus)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Gallus gallus)
canonical WNTs [extracellular region] (Gallus gallus)
WNT3A [extracellular region] (Gallus gallus)
WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Gallus gallus)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [plasma membrane] (Gallus gallus)
WNT3A [extracellular region] (Gallus gallus)
Regulation of FZD by ubiquitination (Gallus gallus)
USP8 deubiquitinates FZD to potentiate WNT signaling (Gallus gallus)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Gallus gallus)
WNT3A [extracellular region] (Gallus gallus)
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6 [plasma membrane] (Gallus gallus)
WNT3A [extracellular region] (Gallus gallus)
ZNRF3 ubiquitinates FZD to promote its downregulation (Gallus gallus)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Gallus gallus)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Gallus gallus)
WNT3A [extracellular region] (Gallus gallus)
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Gallus gallus)
WNT3A [extracellular region] (Gallus gallus)
ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Gallus gallus)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Gallus gallus)
WNT3A [extracellular region] (Gallus gallus)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Gallus gallus)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Gallus gallus)
WNT3A [extracellular region] (Gallus gallus)
WNT ligand biogenesis and trafficking (Gallus gallus)
secretion of WNT ligands (Gallus gallus)
WNTs [extracellular region] (Gallus gallus)
WNT3A [extracellular region] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q2LMP1
Gene Names
WNT3A
Reference Genes
BioGPS Gene:395396 WNT3A
ENSEMBL:ENSGALG00000042657
KEGG:gga:395396 WNT3A
Monarch:395396 WNT3A
NCBI Gene:395396 WNT3A
UCSC:Q2LMP1 WNT3A
Reference Transcript
RefSeq:NM_204675.2 WNT3A
RefSeq:NM_001171601.1 WNT3A
Other Identifiers
395396
GO:0001649
GO:0001701
GO:0001756
GO:0001819
GO:0001947
GO:0002092
GO:0002376
GO:0003713
GO:0005102
GO:0005109
GO:0005125
GO:0005576
GO:0005615
GO:0005640
GO:0005737
GO:0005783
GO:0005886
GO:0006351
GO:0006355
GO:0006366
GO:0007155
GO:0007368
GO:0007409
GO:0007411
GO:0007498
GO:0007507
GO:0008104
GO:0008283
GO:0008284
GO:0009952
GO:0009953
GO:0009986
GO:0010387
GO:0010468
GO:0010628
GO:0010831
GO:0010977
GO:0016055
GO:0019904
GO:0021527
GO:0021766
GO:0021846
GO:0021874
GO:0021904
GO:0022008
GO:0030097
GO:0030154
GO:0030168
GO:0030182
GO:0030198
GO:0030509
GO:0030879
GO:0030890
GO:0030901
GO:0033138
GO:0033278
GO:0035108
GO:0035567
GO:0035914
GO:0036342
GO:0039706
GO:0040036
GO:0042100
GO:0042472
GO:0042802
GO:0043226
GO:0045165
GO:0045202
GO:0045444
GO:0045445
GO:0045595
GO:0045599
GO:0045663
GO:0045743
GO:0045893
GO:0045944
GO:0048018
GO:0048103
GO:0048263
GO:0048337
GO:0048343
GO:0048643
GO:0048697
GO:0048843
GO:0048856
GO:0050679
GO:0050768
GO:0050770
GO:0050804
GO:0050807
GO:0055085
GO:0060070
GO:0060090
GO:0060173
GO:0060828
GO:0060923
GO:0061184
GO:0061303
GO:0062009
GO:0065003
GO:0070507
GO:0070527
GO:0090245
GO:0090263
GO:0090676
GO:0098772
GO:0098978
GO:0140110
GO:1903078
GO:1904339
GO:1904692
GO:1905539
GO:1905606
GO:1990851
GO:2000049
GO:2000179
GO:2000347
GO:2000727
GO:2001141
GT_A_87_P037887
GT_A_87_P055926
Gga.209.1.S1_a_at
Gga.209.2.S1_at
Participates
as a component of
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Gallus gallus)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Gallus gallus)
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6 [plasma membrane] (Gallus gallus)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [plasma membrane] (Gallus gallus)
as a member of
RYK-binding WNTs [extracellular region] (Gallus gallus)
canonical WNTs [extracellular region] (Gallus gallus)
WNTs [extracellular region] (Gallus gallus)
This entity regulates
Negatively
GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405
(Gallus gallus)
Other forms of this molecule
WNT3A [extracellular exosome]
WNT3A [endocytic vesicle membrane]
WNT3A [early endosome membrane]
WNT3A [endoplasmic reticulum lumen]
WNT3A [Golgi lumen]
WNT3A [plasma membrane]
Inferred From
N4GlycoAsn-PalmS WNT3A [extracellular region]
(Homo sapiens)
Modified Residues
Name
N4-glycosyl-L-asparagine at unknown position
PsiMod Name
N4-glycosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.
Name
O-palmitoleyl-L-serine at 209 (in Homo sapiens)
Coordinate
209
PsiMod Name
O-palmitoleyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-palmitoleyl-L-serine.
Cross References
RefSeq
NP_001165072.1
,
NP_990006.2
ENSEMBL
ENSGALT00010063681
,
ENSGALP00010039302
PRO
Q2LMP1
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text