Monoubiquitination of FANCI

Stable Identifier
R-GGA-265973
Type
Reaction [binding]
Species
Gallus gallus
Compartment
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FA protein FANCI has been identified as an ATM/ATR kinase substrate required for cellular resistance to mitomycin C. FANCI shares sequence similarity with FANCD2, likely evolving from a common ancestral gene. The FANCI protein associates with FANCD2 and, together, as the FANCI FANCD2 (ID) complex, localize to chromatin in response to DNA damage. FANCD2-FANCI interdependent monoubiquitination is important for the maintenance of ubiquitin on the other, indicating the existence of a dual ubiquitin-locking mechanism required for ID complex function and hence DNA repair.

Literature References
PubMed ID Title Journal Year
17452773 Identification of the Fanconi anemia complementation group I gene, FANCI

Dorsman, JC, Levitus, M, Rockx, D, Rooimans, MA, Oostra, AB, Haitjema, A, Bakker, ST, Steltenpool, J, Schuler, D, Mohan, S, Schindler, D, Arwert, F, Pals, G, Mathew, CG, Waisfisz, Q, de Winter, JP, Joenje, H

Cell Oncol 2007
17412408 Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair

Smogorzewska, A, Matsuoka, S, Vinciguerra, P, McDonald ER, 3rd, Hurov, KE, Luo, J, Ballif, BA, Gygi, SP, Hofmann, K, D'Andrea, AD, Elledge, SJ

Cell 2007
17460694 FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

Sims, AE, Spiteri, E, Sims RJ, 3rd, Arita, AG, Lach, FP, Landers, T, Wurm, M, Freund, M, Neveling, K, Hanenberg, H, Auerbach, AD, Huang, TT

Nat Struct Mol Biol 2007
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