Binding of RPA heterotrimer to 3' double stranded DNA break

Stable Identifier
R-GGA-265887
Type
Reaction [binding]
Species
Gallus gallus
Compartment
ReviewStatus
5/5
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Upon formation of a double-strand DNA breaks, ssDNA can be formed by a 5’ to 3’ resection from the one of the two ends. The RPA heterotrimer can then bind to the generated ssDNA.
Literature References
PubMed ID Title Journal Year
8396234 DNA unwinding by replication protein A is a property of the 70 kDa subunit and is facilitated by phosphorylation of the 32 kDa subunit

Hübscher, U, Georgaki, A

Nucleic Acids Res 1993
11080452 Reconstitution of the strand invasion step of double-strand break repair using human Rad51 Rad52 and RPA proteins

West, SC, Masson, JY, Stasiak, AZ, Stasiak, A, Van Dyck, E, McIlwraith, MJ

J Mol Biol 2000
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