Reactome | FBXO32 [cytosol]

FBXO32 [cytosol]

Stable Identifier

R-GGA-264453

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

FBXO32, Q5ZHM6

Locations in the PathwayBrowser

Expand all

Immune System (Gallus gallus)

- Adaptive Immune System (Gallus gallus)
  - Class I MHC mediated antigen processing & presentation (Gallus gallus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Gallus gallus)
      - Interaction of E3 with substrate and E2-Ub complex (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
      - Polyubiquitination of substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
      - Release of E3 from polyubiquitinated substrate (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
      - Transfer of Ub from E2 to substrate and release of E2 (Gallus gallus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
        
        E3:Ub:substrate [cytosol] (Gallus gallus)
        
        E3 ligases in proteasomal degradation [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)

Metabolism of proteins (Gallus gallus)

- Post-translational protein modification (Gallus gallus)
  - Neddylation (Gallus gallus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Gallus gallus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Gallus gallus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Gallus gallus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Gallus gallus)
        
        CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
      - CRL E3 ubiquitin ligases [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Gallus gallus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Gallus gallus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Gallus gallus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Gallus gallus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Gallus gallus)
        
        SCF E3 ubiquitin ligase [cytosol] (Gallus gallus)
        
        F-box protein [cytosol] (Gallus gallus)
        
        FBXO32 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:Q5ZHM6

Gene Names

FBXO32

Reference Genes

ENSEMBL:ENSGALG00000041202

ENSEMBL:ENSGALG00010008245.1 FBXO32

KEGG Gene (Gallus gallus):420343 FBXO32

Reference Transcript

Other Identifiers

420343

GO:0003012

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0014894

GO:0016567

GO:0019005

GO:0030018

GO:0036211

GO:0043226

GO:0071549

GT_A_87_P051161

GgaAffx.13211.1.S1_s_at

Participates

as a member of

F-box protein [cytosol] (Gallus gallus)

Inferred From

FBXO32 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015138594.1, NP_001026127.1

OpenTargets

ENSG00000156804

Ensembl

ENSGALG00010008245, ENSGALP00010011272, ENSGALT00010019724

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