CREG(CR1L) binds to surface-bound C3 convertases

Stable Identifier
R-GGA-2530573
Type
Reaction [transition]
Species
Gallus gallus
Compartment
plasma membrane
ReviewStatus
5/5
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CREG(CR1L) binds to surface-bound C3 convertases
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Gene encoding complement regulatory GPI-anchored protein (CREG/CR1L) consists of seven short consensus repeats (SCRs) with relatively high similarity to long homology repeats (LHR) of human CR1 and murine CRY. CREG was shown to protect host cells from chicken complement [Oshiumi H et al 2005].
Literature References
PubMed ID Title Journal Year
16034113 Regulator of complement activation (RCA) locus in chicken: identification of chicken RCA gene cluster and functional RCA proteins

Hattori, T, Tamaki, Y, Yamada, N, Oshiumi, H, Mizuno, S, Goitsuka, R, Seya, T, Matsumoto, M, Ohba, S, Katoh, J, Shida, K, Kimura, Y, Inoue, N

J. Immunol. 2005
11123320 A novel chicken membrane-associated complement regulatory protein: molecular cloning and functional characterization

Fukui, A, Seya, T, Nishizawa, Y, Inoue, N, Matsumoto, M, Toyoshima, K, Nomura, M

J. Immunol. 2001
Participants
Input
Output
Participates
as an event of
Inferred From
CR1 binds C3bBb/C4bC2a (Homo sapiens)
Authored
Shamovsky, V  (2012-12-20)
Reviewed
D'Eustachio, P  (2012-11-07)
Jupe, S  (2013-01-31)
Created
Shamovsky, V  (2012-10-17)
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