Cleaved collagen type X fibril [extracellular region]

Stable Identifier
R-GGA-2484881
Type
Polymer
Species
Gallus gallus
Compartment
extracellular region
General
Collagen X is believed to form extended hexagonal networks (Kwan et al. 1991, Jacenko et al. 2001) in regions of hypertrophic cartilage destined for degradation during endochondral ossification (Schmid & Conrad 1982). It is also found in areas of surface fibrillation and osteophyte formation during the development of osteoarthritic lesions in articular cartilage (von der Mark et al. 1992). In Timp3 knockout mice type X collagen was observed mostly in areas of articular cartilage that stained strongly for collagen cleavage products, suggesting that deposition of type X collagen might be a damage repair mechanism (Sahebjam et al. 2007). Mutations in the gene COL10A1 are associated with Schmid/Japanese type metaphyseal chondrodysplasia (SMCD) (Warman et al. 1993, Ho et al. 2007, Woelfle et al. 2011).

Type X collagen is degraded by MMP1 (Schmid et al. 1986, Welgus et al. 1990, Cole et al. 1993), MMP2 (Cole et al. 1993, Welgus et al. 1990), MMP3 (Wu et al. 1991), MMP13 (Knauper et al. 1997) and neutrophil elastase (Kittelberger et al. 1992).
Literature References
PubMed ID Title Journal Year
2166034 Differential susceptibility of type X collagen to cleavage by two mammalian interstitial collagenases and 72-kDa type IV collagenase

Jeffrey, JJ, Fliszar, CJ, Welgus, HG, Schmid, TM, Seltzer, JL

J Biol Chem 1990
8405676 Type X collagen degradation in long-term serum-free culture of the embryonic chick tibia following production of active collagenase and gelatinase

Boyd, T, Luchene, L, Cole, AA, Kuettner, KE, Schmid, TM

Dev Biol 1993
3005323 Type X collagen contains two cleavage sites for a vertebrate collagenase

Mayne, R, Linsenmayer, TF, Jeffrey, JJ, Schmid, TM

J Biol Chem 1986
Participants
repeated unit
Participates
as an output of
Cite Us!