AGRN binds NCAM1, PTPRS

Stable Identifier
R-GGA-2467642
Type
Reaction [binding]
Species
Gallus gallus
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
AGRN binds NCAM1, PTPRS
Several agrin (AGRN) ligands require the presence of its heparan-sulfate sidechains and probably represent interactions with them. Membrane-associated ligands include the neural cell adhesion molecule NCAM1 (Burg et al. 1995, Tsen et al. 1995, Cole & Halfter 1996 - see REACT_19071) and PTPRS (receptor protein tyrosine phosphatase sigma) (Aricescu et al. 2002).
Literature References
PubMed ID Title Journal Year
11865065 Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma

McKinnell, IW, Halfter, W, Stoker, AW, Aricescu, AR

Mol. Cell. Biol. 2002
7674377 Analysis of proteoglycan expression in developing chicken brain: characterization of a heparan sulfate proteoglycan that interacts with the neural cell adhesion molecule

Halfter, W, Burg, MA, Cole, GJ

J. Neurosci. Res. 1995
Participants
Input
Output
Orthologous Events
AGRN binds NCAM1, PTPRS (Homo sapiens)
Authored
Jupe, S  (2012-06-22)
Reviewed
Ricard-Blum, S  (2013-05-22)
Venkatesan, N  (2013-05-21)
Created
Jupe, S  (2012-09-13)
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