Isomerase II isomerises atROL to 11cROL

Stable Identifier
R-GGA-2465929
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
General
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Isomerase II isomerises atROL to 11cROL
The canonical rod retinoid (visual) cycle is too slow to account for the photosensitivity of cones in bright light conditions. Novel enzyme activities demonstrated in ground-squirrel and chicken retinas produce a novel pathway of chromophore regeneration specific for cones. The first reaction in Muller cells, the isomerization of all-trans-retinol (atROL) to 11-cis-retinol (11cROL), is mediated by an as-yet-uncharacterised atROL isomerase from chicken Muller cells (Mata et al. 2002, Mata et al. 2005).
Literature References
PubMed ID Title Journal Year
16128572 Chicken retinas contain a retinoid isomerase activity that catalyzes the direct conversion of all-trans-retinol to 11-cis-retinol

Travis, GH, Radu, RA, Mata, NL, Ruiz, A, Bui, TV

Biochemistry 2005
12367507 Isomerization and oxidation of vitamin a in cone-dominant retinas: a novel pathway for visual-pigment regeneration in daylight.

Travis, GH, Radu, RA, Clemmons, RC, Mata, NL

Neuron 2002
Participants
Input
Output
Catalyst Activity

retinol isomerase activity of atROL isomerase [endoplasmic reticulum membrane]

Physical Entity
atROL isomerase [endoplasmic reticulum membrane] (Gallus gallus)
Activity
retinol isomerase activity (GO:0050251)
Orthologous Events
An atROL isomerase isomerises atROL to 11cROL (Homo sapiens)
Authored
Jassal, B  (2012-09-04)
Reviewed
Blaner, WS  (2013-01-31)
Created
Jassal, B  (2012-09-04)
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