Expression of both C3 and C5 as well as C3aR and C5aR was detected in chicken liver and eye tissues (Haynes T et al. 2013). Moreover, chicken C3a was shown to stimulate chick retina regeneration through MAPK-STAT3 activation in a C3aR-dependent manner (Haynes T et al. 2013). In addition, functionally active anaphylatoxins and their receptors were found in teleost fish and Xenopus (Rottland J et al. 2004; Boshra H et al. 2004; Holland MC and Lambris JD 2004; Boshra H et al. 2005; Carmona-Fontaine C et al. 2011). The studies in those species suggested that the basic structure and function of anaphylatoxins and their receptors have been conserved for more than 300 million years (Sunyer JO et al. 2005). Taken together, the observations above suggest that the chicken complement signaling may release active fragments C3a and C5a, which associate with C3a and C5a receptors respectively.
van Strijp, J, Haas, PJ
Boshra, H, Peters, R, Parra, D, Rotllant, J, Sunyer, JO
Li, K, Peng, Q, Zhou, W, Sacks, SH
Holland, MC, Lambris, JD
Li, J, Boshra, H, Peters, R, Matlapudi, A, Sunyer, JO, Hansen, J
Li, J, Boshra, H, Hove-Madsen, L, Wang, T, Matlapudi, A, Tort, L, Sunyer, JO, Secombes, CJ, Hansen, J
Li, J, Boshra, H, Sunyer, JO
Tzekou, A, Haynes, T, Echeverri Ruiz, NP, Luz-Madrigal, A, Del Rio-Tsonis, K, Grajales-Esquivel, E, Lambris, JD, Tsonis, PA, Reis, ES
Page, KM, Tzekou, A, Tada, M, Woods, M, Parsons, M, Carmona-Fontaine, C, Lambris, JD, Mayor, R, Theveneau, E
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