Phosphorylation of c-Abl and Arg by ATM

Stable Identifier
R-GGA-217147
Type
Reaction [transition]
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of c-Abl and Arg by ATM
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Upon DNA damage, the inactive ATM dimer auto-phosphorylates, causing dimer dissociation and kinase activation. Activated ATM subsequently phosphorylates Abelson family kinases c-Abl and Arg, which can then phosphorylate Tyr46 of Rad51, leading to the formation of Rad51 nuclear foci.
Literature References
PubMed ID Title Journal Year
18644834 Early events in the mammalian response to DNA double-strand breaks

Riches, LC, Lynch, AM, Gooderham, NJ

Mutagenesis 2008
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Catalyst Activity

protein serine/threonine kinase activity of Activated-ATM kinase [nucleoplasm]

Physical Entity
Activated-ATM kinase [nucleoplasm] (Gallus gallus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Saxena, A  (2008-01-04)
Reviewed
Borowiec, JA  (2009-04-24)
Created
Saxena, A  (2008-03-26)
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