Formation of the Rad17-RFC alternate clamp-loader complex

Stable Identifier
R-GGA-217097
Type
Reaction [binding]
Species
Gallus gallus
Compartment
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The vertebrate Rad17 protein is structurally related to largest subunit of replication factor C (RFC1) and associates with four smaller RFC subunits (RFC2-5). The Rad17-RFC complex, an alternate clamp loader, recognizes the primer-template junction during DNA replication. In a process similar to that occurring in yeast homologs, the Rad17-RFC complex then recruits and loads 9-1-1 complexes to DNA lesions, stimulating subsequent activation of the Chk1 kinase in an early phase of the intra-S-phase checkpoint.

Literature References
PubMed ID Title Journal Year
17575048 The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1

Delacroix, S, Wagner, JM, Kobayashi, M, Yamamoto, K, Karnitz, LM

Genes Dev 2007
15066121 Critical role for chicken Rad17 and Rad9 in the cellular response to DNA damage and stalled DNA replication

Kobayashi, M, Hirano, A, Kumano, T, Xiang, SL, Mihara, K, Haseda, Y, Matsui, O, Shimizu, H, Yamamoto, K

Genes Cells 2004
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