Deubiquitination of FancD2

Stable Identifier
R-GGA-217017
Type
Reaction [transition]
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
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Deubiquitination of FancD2
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Mono-ubiquitination of FANCD2 promotes DNA repair. This modification is necessary for chromatin accumulation of FANCD2. USP1, a protease that removes mono-ubiquitin from FANCD2, was initially thought to reverse the DNA damage role of these repair factors. However, while USP1 ablation increases FANCD2 and PCNA mono-ubiquitination, it also unexpectedly results in an increase in sensitivity to DNA crosslinkers. This defective DNA repair correlates with constitutively chromatin bound and mono-ubiquitinated FANCD2, indicating that efficient DNA crosslink repair requires FANCD2 deubiquitination. Unlike in mammalian cells, accumulation of FANCD2 monoubiquitination in chicken cells upon DNA damage is not dependent on USP1 autocleavage.
Literature References
PubMed ID Title Journal Year
18082605 Deubiquitination of FANCD2 is required for DNA crosslink repair

Patel, KJ, Takata, M, Kuiken, HJ, Ohzeki, M, Niedzwiedz, W, Langevin, F, Pace, P, Simpson, LJ, Sale, JE, Oestergaard, VH

Mol Cell 2007
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Catalyst Activity

cysteine-type deubiquitinase activity of USP1 [nucleoplasm]

Physical Entity
USP1 [nucleoplasm] (Gallus gallus)
Activity
cysteine-type deubiquitinase activity (GO:0004843)
Authored
Saxena, A  (2008-01-28)
Reviewed
Borowiec, JA  (2009-04-24)
Created
Saxena, A  (2008-03-26)
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