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phospho-MAPK8 [nucleoplasm]
Stable Identifier
R-GGA-216349
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
nucleoplasm
Synonyms
p-T,Y-MAPK8, A0A3Q2TY19
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular Senescence (Gallus gallus)
Oxidative Stress Induced Senescence (Gallus gallus)
Activated JNKs phosphorylate c-JUN (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Activated human JNKs migrate to nucleoplasm (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
DNA Repair (Gallus gallus)
DNA Double-Strand Break Repair (Gallus gallus)
DNA Double Strand Break Response (Gallus gallus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Gallus gallus)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Gallus gallus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-17 signaling (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated human JNKs migrate to nucleoplasm (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
Activation of the AP-1 family of transcription factors (Gallus gallus)
Activated JNKs phosphorylate c-JUN (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Innate Immune System (Gallus gallus)
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated MAPK activation (Gallus gallus)
Activated JNKs phosphorylate c-JUN (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Activated human JNKs migrate to nucleoplasm (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 10 (TLR10) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated human JNKs migrate to nucleoplasm (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
Activation of the AP-1 family of transcription factors (Gallus gallus)
Activated JNKs phosphorylate c-JUN (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated human JNKs migrate to nucleoplasm (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
Activation of the AP-1 family of transcription factors (Gallus gallus)
Activated JNKs phosphorylate c-JUN (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated human JNKs migrate to nucleoplasm (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
Activation of the AP-1 family of transcription factors (Gallus gallus)
Activated JNKs phosphorylate c-JUN (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Toll Like Receptor 3 (TLR3) Cascade (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated human JNKs migrate to nucleoplasm (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
Activation of the AP-1 family of transcription factors (Gallus gallus)
Activated JNKs phosphorylate c-JUN (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated human JNKs migrate to nucleoplasm (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
Activation of the AP-1 family of transcription factors (Gallus gallus)
Activated JNKs phosphorylate c-JUN (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated human JNKs migrate to nucleoplasm (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
Activation of the AP-1 family of transcription factors (Gallus gallus)
Activated JNKs phosphorylate c-JUN (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Toll Like Receptor 5 (TLR5) Cascade (Gallus gallus)
MyD88 cascade initiated on plasma membrane (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated human JNKs migrate to nucleoplasm (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
Activation of the AP-1 family of transcription factors (Gallus gallus)
Activated JNKs phosphorylate c-JUN (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated human JNKs migrate to nucleoplasm (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
Activation of the AP-1 family of transcription factors (Gallus gallus)
Activated JNKs phosphorylate c-JUN (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Toll Like Receptor 9 (TLR9) Cascade (Gallus gallus)
MyD88 dependent cascade initiated on endosome (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
MAP kinase activation (Gallus gallus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Gallus gallus)
Activated human JNKs migrate to nucleoplasm (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
Activation of the AP-1 family of transcription factors (Gallus gallus)
Activated JNKs phosphorylate c-JUN (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Phosphorylated MAPKs phosphorylate ATF-2 (Gallus gallus)
Activated MAPK kinases ERK1/2, JNK, p38 [nucleoplasm] (Gallus gallus)
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
Signal Transduction (Gallus gallus)
Death Receptor Signaling (Gallus gallus)
p75 NTR receptor-mediated signalling (Gallus gallus)
Cell death signalling via NRAGE, NRIF and NADE (Gallus gallus)
NRAGE signals death through JNK (Gallus gallus)
Active JNK moves to the nucleus and phosphorylates different transcription factors (Gallus gallus)
phospho-MAPK8 [nucleoplasm] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A3Q2TY19
Gene Names
MAPK8
Reference Genes
BioGPS Gene:423778 MAPK8
ENSEMBL:ENSGALG00000006109
ENSEMBL:ENSGALG00010020460.1 MAPK8
Monarch:423778 MAPK8
NCBI Gene:423778 MAPK8
Reference Transcript
RefSeq:XM_004942132.2 MAPK8
Other Identifiers
423778
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004705
GO:0004707
GO:0005524
GO:0005634
GO:0005737
GO:0006468
GO:0007254
GO:0009612
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0036211
GO:0043065
GO:0043226
GO:0048511
GO:0106310
GO:0140096
GT_A_87_P017981
GT_A_87_P022710
GT_A_87_P080651
Gga.1147.1.S1_at
Gga.1147.1.S1_s_at
Gga.13007.1.S1_at
GgaAffx.3808.1.S1_at
Participates
as an input of
APBB1 and MAPK8 bind diphosphorylated H2AFX (Gallus gallus)
as a component of
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Gallus gallus)
as an output of
Active JNK moves to the nucleus and phosphorylates different transcription factors (Gallus gallus)
as a member of
p-MAPK8,9,10 [nucleoplasm] (Gallus gallus)
Other forms of this molecule
MAPK8 [cytosol]
phospho-MAPK8 [cytosol]
Inferred From
p-T,Y-MAPK8 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_004942189.1
OpenTargets
ENSG00000107643
Ensembl
ENSGALP00010029248
,
ENSGALG00010020460
,
ENSGALT00010049493
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