Formation of fluid-phase convertase C3

Stable Identifier
R-GGA-2132293
Type
Pathway
Species
Gallus gallus
ReviewStatus
5/5
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Formation of fluid-phase convertase C3
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In human, small amounts of hydrolyzed C3 (C3(H20) or C3i) are continuously formed in the fluid phase following spontaneous hydrolysis of the internal thioester bond of C3. C3i can bind to factor B which, in turn, is cleaved by factor D yielding an alternative fluid-phase C3 convertase, C3i:Bb.

Chicken factor B-like protease was shown to create a functional C3 convertase [Jensen LB & Koch C 1991]. Although an orthologue of human factor D has not been identified in the chicken genome, this chicken module describes a cleavage of factor B-like protease as an essential step of the chicken alternative complement pathway.

Literature References
PubMed ID Title Journal Year
2060687 An assay for complement factor B in species at different levels of evolution

Jensen, LB, Koch, C

Dev. Comp. Immunol. 1991
6586103 Initiation of the alternative complement pathway due to spontaneous hydrolysis of the thioester of C3

Pangburn, MK, Muller-Eberhard, HJ

Ann N Y Acad Sci 1983
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Authored
Shamovsky, V  (2012-12-20)
Reviewed
D'Eustachio, P  (2012-11-07)
Jupe, S  (2013-01-31)
Created
Shamovsky, V  (2012-02-21)
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