Lectin-mediated initiation of complement cascade

Stable Identifier
R-GGA-2132270
Type
Pathway
Species
Gallus gallus
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Activation of lectin pathway begins when mannan-binding lectin (MBL, also called mannose-binding protein, MBP) or ficolins bind to cell-surface carbohydrates on the target cell in the presence of Ca2+. Surface bound lectins are assembled with MBL-associated serine proteases (MASPs) [Turner MW et al 1996, Fujita T et al 2004]. The lectin-MASP complex cleaves C4 and C2 complements to generate their active fragments. The active fragments - C4b and C2b, form C3 convertase [Wallis R et al 2007].

Most of the components of chicken lectin pathway (MBL, ficolin, MASP2, MASP3, MAp19) have been mapped, cloned and characterized (Laursen SB and Nielsen OL 2000; Lynch NJ et al 2005).

Literature References
PubMed ID Title Journal Year
15814730 Composition of the lectin pathway of complement in Gallus gallus: absence of mannan-binding lectin-associated serine protease-1 in birds

Lynch, NJ, Khan, SU, Stover, CM, Sandrini, SM, Marston, D, Presanis, JS, Schwaeble, WJ

J Immunol 2005
10717281 Mannan-binding lectin (MBL) in chickens: molecular and functional aspects

Laursen, SB, Nielsen, OL

Dev Comp Immunol 2000
8792471 The lectin pathway of complement activation

Turner, MW

Res Immunol 1996
12033740 Evolution of the lectin-complement pathway and its role in innate immunity

Fujita, T

Nat Rev Immunol 2002
15199963 The lectin-complement pathway--its role in innate immunity and evolution

Fujita, T, Matsushita, M, Endo, Y

Immunol Rev 2004
17204478 Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway

Wallis, R, Dodds, AW, Mitchell, DA, Sim, RB, Reid, KB, Schwaeble, WJ

J Biol Chem 2007
  Current Topics in Complement

Lambris, JD

  2008
17954581 An assay for measuring the mannan-binding lectin pathway of complement activation in chickens

Norup, LR, Juul-Madsen, HR

Poult Sci 2007
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