C4b binds to target cell surface

Stable Identifier
R-GGA-2132248
Type
Reaction [binding]
Species
Gallus gallus
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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C4b binds to target cell surface
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Cleavage of C4 exposes an active thioester bond on the large fragment C4b that allows it to bind covalently to hydroxyl or amino groups on target surfaces. This binding is regulated by the hydrolysis reaction that irreversibly inactivates C4b [Law SK and Dodds AW 1997; Dodds AW et al 1996]. Surface-bound C4b forms the basis for the formation of C3/C5 convertases.

This event was inferred from the curated human reaction.

Literature References
PubMed ID Title Journal Year
17954581 An assay for measuring the mannan-binding lectin pathway of complement activation in chickens

Juul-Madsen, HR, Norup, LR

Poult Sci 2007
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Inferred From
C4b binds to cell surface (Homo sapiens)
Authored
Shamovsky, V  (2012-12-20)
Reviewed
D'Eustachio, P  (2012-11-07)
Jupe, S  (2013-01-31)
Created
Shamovsky, V  (2012-02-21)
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