CD59 binds C5b:C6:C7:C8

Stable Identifier
R-GGA-2132247
Type
Reaction [binding]
Species
Gallus gallus
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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CD59 binds C5b:C6:C7:C8
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Mammalian CD59, the major inhibitor of the complement membrane attack complex (MAC), is an 18-20 kDa glycoprotein, linked to the membrane via a glycosylphosphatidylinositol (GPI)-anchor. It interacts with complement components C8 and C9 during assembly of the membrane attack complex (MAC) and inhibits C9 polymerization, thus preventing the formation of MAC (Lehto T and Meri S. 1993; Rollins SA et al. 1991).

RT-PCR analysis revealed that chicken CD59 mRNA is expressed in brain, heart, lung, spleen, liver, stomach and kidney. It is fully expressed in the following developmental stages: whole embryo 4- and 6-day old, embryo liver of 12- and 17-day old and neonate 2- and 5-day old (Mikrou A and Zarkadis IK 2010).

The module represents hypothetical chicken CD59, which may not have an identifier assigned in any of genome databases. The binding of chicken CD59 to MAC has not been verified experimentally but is inferred from properties of the human proteins.

Literature References
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Output
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as an event of
Inferred From
CD59 inhibits MAC formation (Homo sapiens)
Authored
Shamovsky, V  (2012-12-20)
Reviewed
D'Eustachio, P  (2012-11-07)
Jupe, S  (2013-01-31)
Created
Shamovsky, V  (2012-02-21)
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