Reactome | Complement factor B binds to the hydrolyzed form of C3

Complement factor B binds to the hydrolyzed form of C3

Stable Identifier

R-GGA-2132104

Type

Reaction [binding]

Species

Gallus gallus

Compartment

extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Complement factor B binds to the hydrolyzed form of C3

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Thioester bond hydrolysis results in conformational changes of C3 allowing it to bind factor B.

Literature References

PubMed ID	Title	Journal	Year
2587932	Purification of chicken C3 and a structural and functional characterization Laursen, I, Koch, C	Scand J Immunol	1989
7532662	Isolation, primary structure, and evolution of the third component of chicken complement and evidence for a new member of the alpha 2-macroglobulin family Mavroidis, M, Lambris, JD, Sunyer, JO	J Immunol	1995
6586103	Initiation of the alternative complement pathway due to spontaneous hydrolysis of the thioester of C3 Pangburn, MK, Muller-Eberhard, HJ	Ann N Y Acad Sci	1983

Participants

Input

Output

C3i:factor B [extracellular region] (Gallus gallus)

Participates

as an event of

Formation of fluid-phase convertase C3 (Gallus gallus)

Inferred From

Factor B binds to C3(H2O) (Homo sapiens)

Authored

Shamovsky, V (2012-12-20)

Reviewed

D'Eustachio, P (2012-11-07)

Jupe, S (2013-01-31)

Created

Shamovsky, V (2012-02-21)

Cite Us!