Reactome | Fluid-phase proteolytic cleavage of factor B

Fluid-phase proteolytic cleavage of factor B

Stable Identifier

R-GGA-2132100

Type

Reaction [transition]

Species

Gallus gallus

Compartment

extracellular region

ReviewStatus

5/5

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Fluid-phase proteolytic cleavage of factor B

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In mammals, fluid-phase C3i interacts with factor B which, in turn, is cleaved by factor D, yielding fluid-phase (C3i:Bb) alternative pathway C3 convertase. Mammalian factor D circulates in the plasma in its active enzymatic form but can only cleave C3b-bound factor B, not free factor B.

Although an orthologue of human factor D is not identified in the chicken genome, published data demonstrated the presence of alternative complement pathway (ACP) activity in chicken [Otha H et al 1983; Otha H et al 1984; Laursen I and Koch C 1989; Mavrodis M et al 1995; Koch C 1986]. This project annotates a hypothetical protein of factor D and describes a cleavage of factor B-like protease into an N-terminal Ba fragment of 37 kDa and a C-terminal Bb fragment of 60 kDa. These two fragments, alongside with chicken factor B-like protease, were purified and characterized [Kjalke M et al 1993].

Literature References

PubMed ID	Title	Journal	Year
6315584	Activation of chicken alternative complement pathway by fowlpox virus-infected cells Kai, C, Ohta, H, Yamanouchi, K, Yoshikawa, Y	Infect. Immun.	1983
8409391	Structural analysis of chicken factor B-like protease and comparison with mammalian complement proteins factor B and C2 Welinder, KG, Koch, C, Kjalke, M	J Immunol	1993
2587932	Purification of chicken C3 and a structural and functional characterization Laursen, I, Koch, C	Scand J Immunol	1989
6430791	Lysis of horse red blood cells mediated by antibody-independent activation of the alternative pathway of chicken complement Kai, C, Okada, H, Ohta, H, Yamanouchi, K, Yoshikawa, Y	Immunology	1984
3646826	The alternative complement pathway in chickens. Purification of factor B and production of a monospecific antibody against it Koch, C	Acta Pathol Microbiol Immunol Scand C	1986
7532662	Isolation, primary structure, and evolution of the third component of chicken complement and evidence for a new member of the alpha 2-macroglobulin family Mavroidis, M, Lambris, JD, Sunyer, JO	J Immunol	1995
6586103	Initiation of the alternative complement pathway due to spontaneous hydrolysis of the thioester of C3 Pangburn, MK, Muller-Eberhard, HJ	Ann N Y Acad Sci	1983

Participants

Input

C3i:factor B [extracellular region] (Gallus gallus)

Output

Participates

as an event of

Formation of fluid-phase convertase C3 (Gallus gallus)

Catalyst Activity

serine-type endopeptidase activity of complement factor D [extracellular region]

Physical Entity

complement factor D [extracellular region] (Gallus gallus)

Activity

serine-type endopeptidase activity (GO:0004252)

Inferred From

Factor D cleaves C3(H2O)-bound Factor B (Homo sapiens)

Authored

Shamovsky, V (2012-12-20)

Reviewed

D'Eustachio, P (2012-11-07)

Jupe, S (2013-01-31)

Created

Shamovsky, V (2012-02-21)