C8 binds to C5b:C6:C7 complement complex

Stable Identifier
R-GGA-2132094
Type
Reaction [binding]
Species
Gallus gallus
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
C8 binds to C5b:C6:C7 complement complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In mammals, C8 binds to the membrane-bound C5b:C6:C7 complex. Some lytic activity is expressed by C5b-C8 alone, although efficient hemolytic activity of complement is achieved upon interaction of C5b-C8 complex with complement C9. Mammalian C8 consist of 3 chains - alpha and gamma chains are covalently linked by a disulfide bond, while beta chain is bound by noncovalent forces. This module annotates predicted chicken amino acid sequences of C8 alpha, C8 beta and C8 gamma.
Literature References
Participants
Input
Output
Participates
as an event of
Inferred From
C8 binds C5b:C6:C7 (Homo sapiens)
Authored
Shamovsky, V  (2012-12-20)
Reviewed
D'Eustachio, P  (2012-11-07)
Jupe, S  (2013-01-31)
Created
Shamovsky, V  (2012-02-21)
Cite Us!