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phospho-JAK2 [cytosol]
Stable Identifier
R-GGA-210621
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
p-JAK2, A0A8V0YNY4
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by CSF3 (G-CSF) (Gallus gallus)
Inactivation of CSF3 (G-CSF) signaling (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-12 family signaling (Gallus gallus)
Interleukin-12 signaling (Gallus gallus)
IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated (Gallus gallus)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated (Gallus gallus)
IL12A:IL12B:IL12RB1:p-Y-TYK2:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
STAT4 binds to IL12RB2 in Interleukin-12 receptor complex (Gallus gallus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2:2xSTAT4 [plasma membrane] (Gallus gallus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
p-Y693-STAT4 dissociates after IL12:IL12R interaction (Gallus gallus)
2xp-Y693-STAT4:IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12A:IL12B:IL12RB1:p-Y800-IL12RB2:p-Y-TYK2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
Interleukin-23 signaling (Gallus gallus)
STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
Interleukin-35 Signalling (Gallus gallus)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Gallus gallus)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Gallus gallus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Gallus gallus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4 (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Gallus gallus)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated (Gallus gallus)
IL35:(IL6ST:p-JAK1:p-JAK2:p-TYK2) dimer [plasma membrane] (Gallus gallus)
IL6ST:p-JAK1:p-JAK2:p-TYK2 [plasma membrane] (Gallus gallus)
p-JAK1,p-JAK2,p-TYK2 [cytosol] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1 (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4 (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
JAK2 in IL12RB2:IL12RB2 receptor is phosphorylated (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
STAT1 and STAT4 associate with IL12RB2:IL6ST receptor (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane] (Gallus gallus)
STAT1:IL12A:EBI3:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
STAT1 associates with IL6ST:IL6ST (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer: STAT1 [plasma membrane] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
STAT4 binds IL12RB2:IL12RB2 (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer:STAT4 [plasma membrane] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT4 [plasma membrane] (Gallus gallus)
IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
p-STAT1 dissociates from IL6ST:IL6ST (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer:p-STAT1 [plasma membrane] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
p-STAT4 dissociates from IL12RB2:IL12RB2 receptor (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer:p-STAT4 [plasma membrane] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
phospho-JAK2 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:A0A8V0YNY4
Gene Names
JAK2
Reference Genes
ENSEMBL:ENSGALG00010012833.1
UCSC:A0A8V0YNY4 JAK2
Other Identifiers
374199
GO:0000166
GO:0001774
GO:0001819
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005102
GO:0005131
GO:0005143
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005901
GO:0005925
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006366
GO:0006468
GO:0007155
GO:0007165
GO:0007167
GO:0007259
GO:0008284
GO:0008285
GO:0009898
GO:0010572
GO:0010811
GO:0012501
GO:0012505
GO:0016020
GO:0016301
GO:0016740
GO:0019221
GO:0019897
GO:0019901
GO:0020037
GO:0022407
GO:0030099
GO:0030154
GO:0030163
GO:0030218
GO:0030526
GO:0030546
GO:0031234
GO:0031663
GO:0032729
GO:0032731
GO:0032760
GO:0032819
GO:0033209
GO:0034050
GO:0034612
GO:0035166
GO:0035401
GO:0035556
GO:0035722
GO:0036016
GO:0038043
GO:0038065
GO:0038155
GO:0038156
GO:0038157
GO:0038162
GO:0038163
GO:0042022
GO:0042102
GO:0042169
GO:0042393
GO:0042802
GO:0042981
GO:0043066
GO:0043161
GO:0043687
GO:0045063
GO:0045121
GO:0045348
GO:0045944
GO:0046427
GO:0046677
GO:0048856
GO:0050727
GO:0050867
GO:0051142
GO:0051897
GO:0060391
GO:0060396
GO:0060397
GO:0060399
GO:0060400
GO:0070665
GO:0070671
GO:0071222
GO:0071549
GO:0072536
GO:0097191
GO:0098542
GO:0098772
GO:0120162
GO:0140096
GO:0140546
GO:1900016
GO:1901731
GO:1902533
GO:1905869
GO:2001235
GT_A_87_P015010
GT_A_87_P035335
GT_A_87_P057041
GT_A_87_P092401
GT_A_87_P115868
Gga.3933.1.S1_at
Gga.9173.1.S1_at
Gga.954.1.S1_at
Gga.954.3.S1_a_at
Participates
as a component of
p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
IL-35:(IL6ST:p-JAK1:p-JAK2) dimer [plasma membrane] (Gallus gallus)
IL35:(IL12RB2:p-JAK2) dimer [plasma membrane] (Gallus gallus)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Gallus gallus)
p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
IL12RB2:p-JAK2 [plasma membrane] (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [lysosomal membrane] (Gallus gallus)
CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Gallus gallus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] (Gallus gallus)
as a member of
p-JAK1,p-JAK2,p-TYK2 [cytosol] (Gallus gallus)
Other forms of this molecule
phospho-JAK2 [cytosol]
phospho-JAK2 [cytosol]
JAK2 [endosome lumen]
phospho-JAK2 [cytosol]
phospho-JAK2 [cytosol]
JAK2 [cytosol]
Inferred From
p-JAK2 [cytosol]
(Homo sapiens)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
ENSEMBL
ENSGALP00010017849
,
ENSGALG00010012833
,
ENSGALT00010030775
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