Reactome | ELMO1 [cytosol]

ELMO1 [cytosol]

Stable Identifier

R-GGA-200932

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

Q5ZL97

Locations in the PathwayBrowser

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Immune System (Gallus gallus)

- Innate Immune System (Gallus gallus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Gallus gallus)
    - Regulation of actin dynamics for phagocytic cup formation (Gallus gallus)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1 [cytosol] (Gallus gallus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1 [cytosol] (Gallus gallus)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1 [cytosol] (Gallus gallus)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1 [cytosol] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Signaling by Non-Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by PTK6 (Gallus gallus)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Gallus gallus)
      - Activation of RAC1 by the PXN:CRK complex (Gallus gallus)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1 [cytosol] (Gallus gallus)
      - Phosphorylated PXN recruits the CRK complex (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1 [cytosol] (Gallus gallus)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1 [cytosol] (Gallus gallus)
- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by VEGF (Gallus gallus)
    - VEGFA-VEGFR2 Pathway (Gallus gallus)
      - DOCK180:ELMO binds CRK (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1 [cytosol] (Gallus gallus)
        
        DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1 [cytosol] (Gallus gallus)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1 [cytosol] (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Gallus gallus)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1,ELMO2 [cytosol] (Gallus gallus)
        
        ELMO1 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:Q5ZL97

Reference Genes

BioGPS Gene:420735

ENSEMBL:ENSGALG00000035492

KEGG Gene (Gallus gallus):420735

Monarch:420735

NCBI Gene:420735

Reference Transcript

Participates

as a member of

ELMO1,ELMO2 [cytosol] (Gallus gallus)

Inferred From

ELMO1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_015137027.1, XP_015137030.1, XP_015137025.1, NP_001026165.1, XP_015137022.1, XP_015137029.1, XP_015137023.1, XP_015137028.1, XP_015137024.1, XP_015137026.1