Reactome | RPS6KA2 [nucleoplasm]

RPS6KA2 [nucleoplasm]

Stable Identifier

R-GGA-199861

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

nucleoplasm

Synonyms

RPS6KA2, A0A3Q2UBK0

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Gallus gallus)

- Cellular responses to stress (Gallus gallus)
  - Cellular Senescence (Gallus gallus)
    - Senescence-Associated Secretory Phenotype (SASP) (Gallus gallus)
      - ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA2 [nucleoplasm] (Gallus gallus)

Immune System (Gallus gallus)

- Cytokine Signaling in Immune system (Gallus gallus)
  - Signaling by Interleukins (Gallus gallus)
    - Interleukin-17 signaling (Gallus gallus)
      - MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA2 [nucleoplasm] (Gallus gallus)
- Innate Immune System (Gallus gallus)
  - Toll-like Receptor Cascades (Gallus gallus)
    - Toll Like Receptor 10 (TLR10) Cascade (Gallus gallus)
      - MyD88 cascade initiated on plasma membrane (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA2 [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA2 [nucleoplasm] (Gallus gallus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA2 [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 3 (TLR3) Cascade (Gallus gallus)
      - MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA2 [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
      - MyD88-independent TLR4 cascade (Gallus gallus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA2 [nucleoplasm] (Gallus gallus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA2 [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 5 (TLR5) Cascade (Gallus gallus)
      - MyD88 cascade initiated on plasma membrane (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA2 [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Gallus gallus)
      - MyD88 dependent cascade initiated on endosome (Gallus gallus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA2 [nucleoplasm] (Gallus gallus)
    - Toll Like Receptor 9 (TLR9) Cascade (Gallus gallus)
      - MyD88 dependent cascade initiated on endosome (Gallus gallus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
        
        MAP kinase activation (Gallus gallus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA2 [nucleoplasm] (Gallus gallus)

Signal Transduction (Gallus gallus)

- Signaling by GPCR (Gallus gallus)
  - GPCR downstream signalling (Gallus gallus)
    - G alpha (q) signalling events (Gallus gallus)
      - Gastrin-CREB signalling pathway via PKC and MAPK (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA2 [nucleoplasm] (Gallus gallus)
- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by NTRKs (Gallus gallus)
    - Signaling by NTRK1 (TRKA) (Gallus gallus)
      - Nuclear Events (kinase and transcription factor activation) (Gallus gallus)
        
        ERK/MAPK targets (Gallus gallus)
        
        ERK1/2/5 activate RSK1/2/3 (Gallus gallus)
        
        Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)
        
        RPS6KA2 [nucleoplasm] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A3Q2UBK0

Gene Names

RPS6KA2

Reference Genes

ENSEMBL:ENSGALG00000011473

ENSEMBL:ENSGALG00010005839.1 RPS6KA2

Other Identifiers

421570

GO:0000166

GO:0000287

GO:0003824

GO:0004672

GO:0004674

GO:0004711

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0006468

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0035556

GO:0036211

GO:0043226

GO:0140096

GT_A_87_P038668

GgaAffx.7275.1.S1_at

GgaAffx.7275.2.S1_s_at

GgaAffx.7275.3.S1_s_at

Participates

as a member of

Ribosomal protein S6 kinase [nucleoplasm] (Gallus gallus)

Other forms of this molecule

phospho-RPS6KA2 [nucleoplasm]

phospho-RPS6KA2 [cytosol]

phospho-RPS6KA2 [nucleoplasm]

Inferred From

RPS6KA2 [nucleoplasm] (Homo sapiens)

Cross References

OpenTargets

ENSG00000071242

Ensembl

ENSGALG00010005839, ENSGALP00010008215, ENSGALT00010013927

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