Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
PI3K alpha [cytosol]
Stable Identifier
R-GGA-198379
Type
Complex
Species
Gallus gallus
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
RET signaling (Gallus gallus)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
GPVI-mediated activation cascade (Gallus gallus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Gallus gallus)
PI3K alpha, beta, gamma [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Costimulation by the CD28 family (Gallus gallus)
CD28 co-stimulation (Gallus gallus)
CD28 dependent PI3K/Akt signaling (Gallus gallus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
CD28:PI3K [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
PI3K binds CD28 (Gallus gallus)
CD28:PI3K [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
PI3K binds ICOS (Gallus gallus)
ICOS:PI3K [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-2 family signaling (Gallus gallus)
Interleukin receptor SHC signaling (Gallus gallus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Gallus gallus)
14-3-3 zeta binding allows recruitment of PI3K (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
Interleukin receptor SHC signaling (Gallus gallus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Gallus gallus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
Regulation of signaling by CBL (Gallus gallus)
CBL ubiquitinates PI3K (Gallus gallus)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Gallus gallus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Intracellular signaling by second messengers (Gallus gallus)
PIP3 activates AKT signaling (Gallus gallus)
Negative regulation of the PI3K/AKT network (Gallus gallus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
CD28:PI3K [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
ICOS:PI3K [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
Activator:PI3K [plasma membrane] (Gallus gallus)
CD28:PI3K [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
ICOS:PI3K [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
RAC1,RAC2,RHOG activate PI3K (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (q) signalling events (Gallus gallus)
G alpha (q) inhibits PI3K alpha (Gallus gallus)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
Signaling by Nuclear Receptors (Gallus gallus)
ESR-mediated signaling (Gallus gallus)
Extra-nuclear estrogen signaling (Gallus gallus)
PI3K binds membrane-associated estrogen receptors (Gallus gallus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
PTK2 is recruited to methylated ESR1 (Gallus gallus)
Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Gallus gallus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by SCF-KIT (Gallus gallus)
Direct recruitment of PI3K to p-KIT (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
Synthesis of PIP3 from PIP2 by PI3K (Gallus gallus)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Gallus gallus)
Signaling by Rho GTPases (Gallus gallus)
RHO GTPase cycle (Gallus gallus)
RAC1 GTPase cycle (Gallus gallus)
RAC1 binds effectors at the plasma membrane (Gallus gallus)
RAC1 effectors [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
RAC1:GTP:RAC1 effectors [plasma membrane] (Gallus gallus)
RAC1 effectors [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
RAC2 GTPase cycle (Gallus gallus)
RAC2 binds effectors at the plasma membrane (Gallus gallus)
RAC2 plasma membrane effectors [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Gallus gallus)
RAC2 plasma membrane effectors [cytosol] (Gallus gallus)
PI3K alpha [cytosol] (Gallus gallus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
PI3K-regulatory subunits [cytosol]
(Gallus gallus)
PIK3CA [cytosol]
(Gallus gallus)
Participates
as a member of
RAC2 plasma membrane effectors [cytosol] (Gallus gallus)
RAC1 effectors [cytosol] (Gallus gallus)
p85-containing Class 1A PI3Ks [cytosol] (Gallus gallus)
PI3K alpha, beta, gamma [cytosol] (Gallus gallus)
as an input of
PI3K binds membrane-associated estrogen receptors (Gallus gallus)
G alpha (q) inhibits PI3K alpha (Gallus gallus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Gallus gallus)
PI3K binds CD28 (Gallus gallus)
Direct recruitment of PI3K to p-KIT (Gallus gallus)
RAC1,RAC2,RHOG activate PI3K (Gallus gallus)
PI3K binds ICOS (Gallus gallus)
as a component of
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Gallus gallus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Gallus gallus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Gallus gallus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
ICOS:PI3K [plasma membrane] (Gallus gallus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Gallus gallus)
CD28:PI3K [plasma membrane] (Gallus gallus)
Inferred From
PI3K alpha [cytosol]
(Homo sapiens)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text