Reactome | T-cell receptor alpha chain V region PY14 precursor [plasma membrane]

T-cell receptor alpha chain V region PY14 precursor [plasma membrane]

Stable Identifier

R-GGA-198176

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

A0A3Q2TUC2

Locations in the PathwayBrowser

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Immune System (Gallus gallus)

- Adaptive Immune System (Gallus gallus)
  - Costimulation by the CD28 family (Gallus gallus)
    - PD-1 signaling (Gallus gallus)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Gallus gallus)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex with dephosphorylated CD3 zeta chain [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Gallus gallus)
    - TCR binds microbial lipid-based antigen via CD1 (Gallus gallus)
      - CD1:B2M:microbial lipid:TCR [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
      - T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
    - TCR binds self-lipid-based antigen via CD1 (Gallus gallus)
      - CD1:B2M:self-lipid:TCR [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
      - T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
    - TCR complex interacts with peptide antigen-presenting MHC Class I (Gallus gallus)
      - T-cell receptor complex with CD8 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
      - TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex with CD8 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
  - TCR signaling (Gallus gallus)
    - Generation of second messenger molecules (Gallus gallus)
      - Phosphorylation of PLC-gamma1 (Gallus gallus)
        
        Activated ZAP-70 [plasma membrane] (Gallus gallus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
    - Phosphorylation of CD3 and TCR zeta chains (Gallus gallus)
      - Activation of Lck (Gallus gallus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
      - Dephosphorylation of Lck-pY505 by CD45 (Gallus gallus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
      - Inactivation of LCK by PTPN22 (Gallus gallus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
      - Inactivation of Lck by Csk (Gallus gallus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
      - Phosphorylation of ITAM motifs in CD3 complexes (Gallus gallus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
    - Translocation of ZAP-70 to Immunological synapse (Gallus gallus)
      - Activation of ZAP-70 (Gallus gallus)
        
        Activated ZAP-70 [plasma membrane] (Gallus gallus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Gallus gallus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
      - PTPN22 dephosphorylates ZAP70 (Gallus gallus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Gallus gallus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Gallus gallus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
      - Phosphorylation of ZAP-70 by Lck (Gallus gallus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Gallus gallus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Gallus gallus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Gallus gallus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Gallus gallus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Gallus gallus)
        
        T-cell receptor complex with phosphorylated ITAMs [plasma membrane] (Gallus gallus)
        
        T-cell receptor [plasma membrane] (Gallus gallus)
        
        TCR chain alpha [plasma membrane] (Gallus gallus)
        
        Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)
        
        T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A3Q2TUC2

Reference Genes

ENSEMBL:ENSGALG00000052634

Participates

as a member of

Homologues of T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Gallus gallus)

Inferred From

T-cell receptor alpha chain V region PY14 precursor [plasma membrane] (Homo sapiens)

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