Reactome | BFIV21 [plasma membrane]

BFIV21 [plasma membrane]

Stable Identifier

R-GGA-197643-17

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

HLA class I histocompatibility antigen, E alpha chain precursor, Q95601

Locations in the PathwayBrowser

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Immune System (Gallus gallus)

- Adaptive Immune System (Gallus gallus)
  - Class I MHC mediated antigen processing & presentation (Gallus gallus)
    - Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Gallus gallus)
      - Expression of peptide bound class I MHC on cell surface (Gallus gallus)
        
        Antigen peptide bound class I MHC [plasma membrane] (Gallus gallus)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Gallus gallus)
        
        MHC Class I [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
    - Antigen processing-Cross presentation (Gallus gallus)
      - ER-Phagosome pathway (Gallus gallus)
        
        Export of peptide loaded MHC class I complex to PM (Gallus gallus)
        
        Antigen peptide bound class I MHC [plasma membrane] (Gallus gallus)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Gallus gallus)
        
        MHC Class I [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
      - Endosomal/Vacuolar pathway (Gallus gallus)
        
        Translocation of peptide bound MHC class I complex to cell surface (Gallus gallus)
        
        Antigen peptide bound class I MHC [plasma membrane] (Gallus gallus)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Gallus gallus)
        
        MHC Class I [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Gallus gallus)
    - KLRC1:KLRD1 heterodimer interacts with HLA-E (Gallus gallus)
      - HLA-E [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
      - HLA-E interacting with KLRC1:KLRD1 [plasma membrane] (Gallus gallus)
        
        HLA-E [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
    - TCR complex interacts with peptide antigen-presenting MHC Class I (Gallus gallus)
      - Antigen peptide bound class I MHC [plasma membrane] (Gallus gallus)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Gallus gallus)
        
        MHC Class I [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
      - TCR interacting with antigen-bearing MHC Class I [plasma membrane] (Gallus gallus)
        
        Antigen peptide bound class I MHC [plasma membrane] (Gallus gallus)
        
        Beta-2-microglobulin:class I MHC heavy chain Complex [plasma membrane] (Gallus gallus)
        
        MHC Class I [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
- Innate Immune System (Gallus gallus)
  - DAP12 interactions (Gallus gallus)
    - DAP12 signaling (Gallus gallus)
      - PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Gallus gallus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Gallus gallus)
        
        DAP12 receptors [plasma membrane] (Gallus gallus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Gallus gallus)
        
        HLA-E [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
      - Phosphorylation and activation of VAV2/VAV3 by SYK (Gallus gallus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Gallus gallus)
        
        DAP12 receptors [plasma membrane] (Gallus gallus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Gallus gallus)
        
        HLA-E [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
      - Phosphorylation of BTK by p-SYK (Gallus gallus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Gallus gallus)
        
        DAP12 receptors [plasma membrane] (Gallus gallus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Gallus gallus)
        
        HLA-E [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Gallus gallus)
        
        p-SYK/p-BTK [plasma membrane] (Gallus gallus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Gallus gallus)
        
        DAP12 receptors [plasma membrane] (Gallus gallus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Gallus gallus)
        
        HLA-E [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
      - Phosphorylation of SLP-76 by p-SYK (Gallus gallus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Gallus gallus)
        
        DAP12 receptors [plasma membrane] (Gallus gallus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Gallus gallus)
        
        HLA-E [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
      - Phosphorylation of SYK (Gallus gallus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Gallus gallus)
        
        DAP12 receptors [plasma membrane] (Gallus gallus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Gallus gallus)
        
        HLA-E [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
        
        DAP12 receptors:p-DAP12:SYK [plasma membrane] (Gallus gallus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Gallus gallus)
        
        DAP12 receptors [plasma membrane] (Gallus gallus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Gallus gallus)
        
        HLA-E [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
      - Recruitment of SYK to p-DAP12 (Gallus gallus)
        
        DAP12 receptors:p-DAP12:SYK [plasma membrane] (Gallus gallus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Gallus gallus)
        
        DAP12 receptors [plasma membrane] (Gallus gallus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Gallus gallus)
        
        HLA-E [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Gallus gallus)
        
        DAP12 receptors [plasma membrane] (Gallus gallus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Gallus gallus)
        
        HLA-E [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
      - p85 regulatory unit of PI3K binds p-6Y-SYK (Gallus gallus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Gallus gallus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Gallus gallus)
        
        DAP12 receptors [plasma membrane] (Gallus gallus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Gallus gallus)
        
        HLA-E [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)
        
        DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Gallus gallus)
        
        DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Gallus gallus)
        
        DAP12 receptors [plasma membrane] (Gallus gallus)
        
        CD94:NKG2C:HLA-E [plasma membrane] (Gallus gallus)
        
        HLA-E [plasma membrane] (Gallus gallus)
        
        Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)
        
        BFIV21 [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:Q95601

Gene Names

BFIV21

Reference Genes

BioGPS Gene:425389 BFIV21

CTD Gene:425389 BFIV21

ENSEMBL:ENSGALG00000041380

KEGG Gene (Gallus gallus):425389 BFIV21

Monarch:425389 BFIV21

NCBI Gene:425389 BFIV21

Reference Transcript

RefSeq:NM_001031338.1 BFIV21

Participates

as a member of

Homologues of HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Gallus gallus)

Other forms of this molecule

BFIV21 [extracellular region]

BFIV21 [plasma membrane]

BFIV21 [extracellular region]

BFIV21 [secretory granule membrane]

BFIV21 [azurophil granule membrane]

BFIV21 [phagocytic vesicle membrane]

BFIV21 [recycling endosome membrane]

BFIV21 [early endosome membrane]

BFIV21 [lumenal side of endoplasmic reticulum membrane]

BFIV21 [plasma membrane]

BFIV21 [ER to Golgi transport vesicle membrane]

BFIV21 [Golgi membrane]

BFIV21 [plasma membrane]

BFIV21 [early endosome membrane]

Inferred From

HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001026509.1

PDB

2YEZ, 3BEV, 4CVZ, 4D0C, 5ACZ, 3BEW, 4D0B, 5AD0

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