carbamoyl phosphate + ornithine => citrulline + orthophosphate

Stable Identifier
R-GGA-187588
Type
Reaction [transition]
Species
Gallus gallus
Compartment
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Mitochondrial ornithine transcarbamylase (OTC) trimer catalyzes the reaction of carbamoyl phosphate and ornithine to form citrulline and orthophosphate. While the enzyme has been purified and characterized (Tamir and Ratner 1963a,b; Tsuji 1983), and the gene encoding it has been cloned (Shimogiri et al. 1998), the physiological role of this reaction is unclear. Indirect studies in vivo indicate that chickens cannot synthesize citrulline from ornithine and the chicken enzyme is undetectable in liver, of low abundance in other tissues such as kidney, and of low specific activity compared to homologous proteins purified in parallel from mammalian sources.

Literature References
PubMed ID Title Journal Year
14064979 Enzymes of arginine metabolism in chicks

Tamir, H, Ratner, S

Arch Biochem Biophys 1963
9792920 Chicken ornithine transcarbamylase gene, structure, regulation, and chromosomal assignment: repetitive sequence motif in intron 3 regulates this enzyme activity

Shimogiri, T, Kono, M, Mannen, H, Mizutani, M, Tsuji, S

J Biochem 1998
6418730 Chicken ornithine transcarbamylase: purification and some properties

Tsuji, S

J Biochem 1983
14061730 A study of ornithine, citrulline and arginine synthesis in growing chicks

Tamir, H, Ratner, S

Arch Biochem Biophys 1963
Participants
Participates
Catalyst Activity

ornithine carbamoyltransferase activity of OTC trimer [mitochondrial matrix]

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