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PTPN11 [cytosol]
Stable Identifier
R-GGA-162563
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
cytosol
Synonyms
Q90687
Locations in the PathwayBrowser
Expand all
Developmental Biology (Gallus gallus)
Nervous system development (Gallus gallus)
Axon guidance (Gallus gallus)
RET signaling (Gallus gallus)
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Hemostasis (Gallus gallus)
Cell surface interactions at the vascular wall (Gallus gallus)
PECAM1 interactions (Gallus gallus)
Interaction of PECAM-1 and SHP-2 (Gallus gallus)
PECAM-1:SHP-2 complex [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Tie2 Signaling (Gallus gallus)
Interaction of Tie2 and Shp2 (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
pTie2 and SHP2 complex [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Platelet homeostasis (Gallus gallus)
Platelet sensitization by LDL (Gallus gallus)
Interaction of PECAM-1 and SHP-2 (Gallus gallus)
PECAM-1:SHP-2 complex [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Regulation of T cell activation by CD28 family (Gallus gallus)
Co-inhibition by CTLA4 (Gallus gallus)
SHP2 phosphatase binds CTLA-4 (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Co-inhibition by PD-1 (Gallus gallus)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Interferon Signaling (Gallus gallus)
Interferon alpha/beta signaling (Gallus gallus)
Regulation of IFNA/IFNB signaling (Gallus gallus)
Dephosphorylation of STAT1 by SHP2 (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Signaling by Interleukins (Gallus gallus)
Interleukin-20 family signaling (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Gallus gallus)
SHP1 and SHP2 bind the common beta chain (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN6,PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Interleukin-6 family signaling (Gallus gallus)
Interleukin-6 signaling (Gallus gallus)
PTPN11 binds CBL (Gallus gallus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Gallus gallus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 binds p-Y759-IL6ST (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 is phosphorylated (Gallus gallus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Innate Immune System (Gallus gallus)
Toll-like Receptor Cascades (Gallus gallus)
Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
MyD88-independent TLR4 cascade (Gallus gallus)
TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Gallus gallus)
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4 (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by EGFR (Gallus gallus)
GAB1 signalosome (Gallus gallus)
Activation of SHP2 through the binding to phospho-Gab1 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Dephosphorylation of Gab1 by SHP2 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Dephosphorylation of PAG by SHP2 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
SHP2 dephosphorylates Tyr 992 on EGFR (Gallus gallus)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Sustained activation of SRC kinase by SHP2 (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Signaling by FGFR (Gallus gallus)
Signaling by FGFR1 (Gallus gallus)
Downstream signaling of activated FGFR1 (Gallus gallus)
FRS-mediated FGFR1 signaling (Gallus gallus)
Activated FGFR1:p-FRS bind to PPTN11 (Gallus gallus)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Gallus gallus)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Signaling by FGFR2 (Gallus gallus)
Downstream signaling of activated FGFR2 (Gallus gallus)
FRS-mediated FGFR2 signaling (Gallus gallus)
Activated FGFR2 phosphorylates PPTN11 (Gallus gallus)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Activated FGFR2:p-FRS bind to PPTN11 (Gallus gallus)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Signaling by FGFR3 (Gallus gallus)
Downstream signaling of activated FGFR3 (Gallus gallus)
FRS-mediated FGFR3 signaling (Gallus gallus)
Activated FGFR3 phosphorylates PPTN11 (Gallus gallus)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Activated FGFR3:p-FRS bind to PPTN11 (Gallus gallus)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Signaling by FGFR4 (Gallus gallus)
Downstream signaling of activated FGFR4 (Gallus gallus)
FRS-mediated FGFR4 signaling (Gallus gallus)
Activated FGFR4 phosphorylates PPTN11 (Gallus gallus)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Activated FGFR4:p-FRS bind to PPTN11 (Gallus gallus)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Signaling by MET (Gallus gallus)
MET activates PTPN11 (Gallus gallus)
GAB1 binds PTPN11 (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Signaling by PDGF (Gallus gallus)
Downstream signal transduction (Gallus gallus)
SHP2 binds to the active receptor (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
Signaling by SCF-KIT (Gallus gallus)
Phosphorylation of SHP2 by SFKs (Gallus gallus)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
SHP2 interacts with p-KIT (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
PTPN11 [cytosol] (Gallus gallus)
External Reference Information
External Reference
UniProt:Q90687
Reference Genes
BioGPS Gene:395815
ENSEMBL:ENSGALG00000004821
KEGG:gga:395815
Monarch:395815
NCBI Entrez Gene:395815
UCSC:Q90687
Reference Transcript
RefSeq:NM_204968.2
Other Identifiers
395815
GO:0000077
GO:0001784
GO:0003013
GO:0003824
GO:0004721
GO:0004725
GO:0004726
GO:0005158
GO:0005634
GO:0005737
GO:0005829
GO:0006470
GO:0006629
GO:0006641
GO:0007165
GO:0007173
GO:0007229
GO:0007409
GO:0007420
GO:0007507
GO:0008543
GO:0009755
GO:0009967
GO:0016311
GO:0016787
GO:0019901
GO:0021697
GO:0030154
GO:0030159
GO:0030220
GO:0030971
GO:0031666
GO:0032331
GO:0032480
GO:0032481
GO:0032528
GO:0032728
GO:0032760
GO:0032991
GO:0033628
GO:0033629
GO:0035264
GO:0035265
GO:0035855
GO:0036302
GO:0038127
GO:0042130
GO:0042311
GO:0042445
GO:0042593
GO:0043254
GO:0043408
GO:0045296
GO:0045778
GO:0045931
GO:0046326
GO:0046628
GO:0046676
GO:0046825
GO:0046887
GO:0046888
GO:0048008
GO:0048011
GO:0048013
GO:0048806
GO:0048839
GO:0048856
GO:0048870
GO:0048873
GO:0050839
GO:0051428
GO:0051463
GO:0051897
GO:0060020
GO:0060090
GO:0060125
GO:0060325
GO:0061582
GO:0070374
GO:0071260
GO:0071364
GO:0140096
GO:1902533
GO:1902564
GO:1990782
GT_A_87_P009085
GT_A_87_P087218
Gga.482.1.S1_at
Participates
as an input of
p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Gallus gallus)
SHP2 interacts with p-KIT (Gallus gallus)
SHP2 binds to the active receptor (Gallus gallus)
SHP2 phosphatase binds CTLA-4 (Gallus gallus)
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Gallus gallus)
PTPN11 binds p-Y759-IL6ST (Gallus gallus)
Activated FGFR2:p-FRS bind to PPTN11 (Gallus gallus)
Activation of SHP2 through the binding to phospho-Gab1 (Gallus gallus)
Interaction of Tie2 and Shp2 (Gallus gallus)
Interaction of PECAM-1 and SHP-2 (Gallus gallus)
GAB1 binds PTPN11 (Gallus gallus)
Activated FGFR1:p-FRS bind to PPTN11 (Gallus gallus)
Activated FGFR4:p-FRS bind to PPTN11 (Gallus gallus)
Activated FGFR3:p-FRS bind to PPTN11 (Gallus gallus)
as a component of
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Gallus gallus)
SHP2:SFKs:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Gallus gallus)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Gallus gallus)
pCTLA-4:Src kinases:SHP2 [plasma membrane] (Gallus gallus)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Gallus gallus)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR2:p-FRS:PTPN11 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Gallus gallus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Gallus gallus)
pTie2 and SHP2 complex [plasma membrane] (Gallus gallus)
PECAM-1:SHP-2 complex [plasma membrane] (Gallus gallus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR4:p-FRS:PTPN11 [plasma membrane] (Gallus gallus)
Activated FGFR3:p-FRS:PTPN11 [plasma membrane] (Gallus gallus)
as a member of
PTPN6,PTPN11 [cytosol] (Gallus gallus)
This entity regulates
Negatively
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4
(Gallus gallus)
Other forms of this molecule
PTPN11 [nucleoplasm]
phospho-p-Y542,Y580-PTPN11 [cytosol]
Inferred From
PTPN11 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_990299.1
ENSEMBL
ENSGALG00010020701
,
ENSGALP00010029554
,
ENSGALT00010050025
PRO
Q90687
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