Reactome | Neuregulins [extracellular region]

Neuregulins [extracellular region]

Stable Identifier

R-GGA-1227957

Type

Set [CandidateSet]

Species

Gallus gallus

Compartment

extracellular region

Synonyms

NRG1/2/3/4

Locations in the PathwayBrowser

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Signal Transduction (Gallus gallus)

- Intracellular signaling by second messengers (Gallus gallus)
  - PIP3 activates AKT signaling (Gallus gallus)
    - Negative regulation of the PI3K/AKT network (Gallus gallus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Gallus gallus)
        
        PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
        
        Activator:PI3K [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
    - PI3K phosphorylates PIP2 to PIP3 (Gallus gallus)
      - Activator:PI3K [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
- MAPK family signaling cascades (Gallus gallus)
  - MAPK1/MAPK3 signaling (Gallus gallus)
    - RAF/MAP kinase cascade (Gallus gallus)
      - RAS GEFs promote RAS nucleotide exchange (Gallus gallus)
        
        RAS GEFs [plasma membrane] (Gallus gallus)
        
        GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Gallus gallus)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Gallus gallus)
        
        p-ERBB4 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4cyt2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
- Signaling by Receptor Tyrosine Kinases (Gallus gallus)
  - Signaling by ERBB2 (Gallus gallus)
    - Downregulation of ERBB2 signaling (Gallus gallus)
      - MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB2 heterodimers:MATK [plasma membrane] (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
      - PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Gallus gallus)
        
        Heterodimers of p-ERBB2 dephosphorylated at Y1248 [plasma membrane] (Gallus gallus)
        
        Phosphorylated p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        Phosphorylated p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
    - ERBB2 Regulates Cell Motility (Gallus gallus)
      - Phosphorylated ERBB2 heterodimers bind MEMO1 (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
    - GRB2 events in ERBB2 signaling (Gallus gallus)
      - GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4cyt2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4cyt2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
      - RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4cyt2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
    - PI3K events in ERBB2 signaling (Gallus gallus)
      - Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
      - PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Gallus gallus)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
    - SHC1 events in ERBB2 signaling (Gallus gallus)
      - SHC1 phosphorylation by ERBB2 heterodimers (Gallus gallus)
        
        SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
    - SRC family kinases phosphorylate ERBB2 (Gallus gallus)
      - ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:ERBB4:ERBB2 [plasma membrane] (Gallus gallus)
        
        ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
      - p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:ERBB4:p-Y877-ERBB2 [plasma membrane] (Gallus gallus)
        
        p-Y877-ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-Y877-ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
    - Trans-autophosphorylation of ERBB2 heterodimers (Gallus gallus)
      - ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:ERBB4:ERBB2 [plasma membrane] (Gallus gallus)
        
        ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
      - p-6Y-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
    - Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Gallus gallus)
      - Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
      - p-Y877-ERBB2 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGFLs:ERBB4:p-Y877-ERBB2 [plasma membrane] (Gallus gallus)
        
        p-Y877-ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-Y877-ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
  - Signaling by ERBB4 (Gallus gallus)
    - ERBB4 binds NRGs or EGF-like ligands (Gallus gallus)
      - NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
      - NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
    - ERBB4 forms heterodimers with EGFR (Gallus gallus)
      - ERBB4:EGFR heterodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
      - NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
    - ERBB4 forms heterodimers with ERBB3 (Gallus gallus)
      - ERBB4:ERBB3 heterodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
      - NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
    - Homodimerization of ERBB4 (Gallus gallus)
      - ERBB4 homodimers [plasma membrane] (Gallus gallus)
        
        ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        ERBB4jmAcyt1 homodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        ERBB4jmBcyt1 homodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        ERBB4jmAcyt2 homodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
      - NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
    - PI3K events in ERBB4 signaling (Gallus gallus)
      - Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Gallus gallus)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
      - Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Gallus gallus)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Gallus gallus)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
    - SHC1 events in ERBB4 signaling (Gallus gallus)
      - Phosphorylation of SHC1 by ERBB4 homodimers (Gallus gallus)
        
        SHC1:p-ERBB4 [plasma membrane] (Gallus gallus)
        
        p-ERBB4 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Gallus gallus)
        
        p-ERBB4 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
      - RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Gallus gallus)
        
        GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Gallus gallus)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Gallus gallus)
        
        p-ERBB4 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
      - Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Gallus gallus)
        
        GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Gallus gallus)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Gallus gallus)
        
        p-ERBB4 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Gallus gallus)
        
        p-ERBB4 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
      - SHC1 binds P-ERBB4 isoform dimers (Gallus gallus)
        
        SHC1:p-ERBB4 [plasma membrane] (Gallus gallus)
        
        p-ERBB4 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
    - Trans-autophosphorylation of ERBB4 homodimers (Gallus gallus)
      - ERBB4 homodimers [plasma membrane] (Gallus gallus)
        
        ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        ERBB4jmAcyt1 homodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        ERBB4jmBcyt1 homodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        ERBB4jmAcyt2 homodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
      - p-ERBB4 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Gallus gallus)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Gallus gallus)
        
        NRGs/EGF-like ligands [extracellular region] (Gallus gallus)
        
        Neuregulins [extracellular region] (Gallus gallus)

Participants

members

NRG1 [extracellular region] (Gallus gallus)

candidates

NRG2 [extracellular region] (Gallus gallus)

Participates

as a member of

NRGs/EGF-like ligands [extracellular region] (Gallus gallus)

Inferred From

Neuregulins [extracellular region] (Homo sapiens)

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