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Negative Regulation of MDA5 signaling
Stable Identifier
R-GGA-1227888
Type
Pathway
Species
Gallus gallus
ReviewStatus
5/5
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Innate Immune System (Gallus gallus)
RLR (RIG-like receptor) mediated induction of IFN alpha/beta (Gallus gallus)
Negative Regulation of MDA5 signaling (Gallus gallus)
General
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Antiviral responses must be tightly regulated in order to prevent uncontrolled production of type I IFN that may lead to damage of host's cells and tissues.
Literature References
PubMed ID
Title
Journal
Year
18703349
Negative regulation of cytoplasmic RNA-mediated antiviral signaling
Horvath, CM
,
Komuro, A
,
Bamming, D
Cytokine
2008
Participants
Events
Inhibition of MDA5-IPS1 signaling by Atg5-Atg12 conjugate
(Gallus gallus)
NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding
(Gallus gallus)
ITCH homolog downregulates MDA5/IPS1 signaling
(Gallus gallus)
NLRX1 inhibits IPS1 signaling
(Gallus gallus)
Participates
as an event of
RLR (RIG-like receptor) mediated induction of IFN alpha/beta (Gallus gallus)
Event Information
Go Biological Process
negative regulation of innate immune response (0045824)
Inferred From
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
Authored
Shamovsky, V (2011-01-05)
Reviewed
Garapati, P V (2011-05-16)
Created
Shamovsky, V (2011-03-10)
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