ITCH homolog downregulates MDA5/IPS1 signaling

Stable Identifier
R-GGA-1227860
Type
Reaction [transition]
Species
Gallus gallus
Related Species
Infectious bronchitis virus
Compartment
mitochondrial outer membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ITCH homolog downregulates MDA5/IPS1 signaling
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Predicted chicken ITCH shows 86% amino acid sequence identiti to its human ortholog. In mammals, ITCH, also known as AIP4 (atrophin 1-interacting protein-4), negatively regulates RLR signaling through Lys-48 linked polyubiquitination of IPS-1 resulting in IPS-1 proteasomal degradation.
Literature References
PubMed ID Title Journal Year
19881509 PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

Sun, W, Jiang, Z, You, F, Liang, S, Sun, H, Zhai, Z, Zhou, X

Nat Immunol 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-ubiquitin ligase activity of ITCH [cytosol]

Physical Entity
ITCH [cytosol] (Gallus gallus)
Activity
ubiquitin-ubiquitin ligase activity (GO:0034450)
Inferred From
Recruitment of ITCH and K48 ubiquitination of MAVS (Homo sapiens)
Authored
Shamovsky, V  (2011-01-05)
Reviewed
Garapati, P V  (2011-05-16)
Created
Shamovsky, V  (2011-03-10)
Cite Us!