NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding.

Stable Identifier
R-GGA-1227695
Type
Reaction [binding]
Species
Gallus gallus
Related Species
Infectious bronchitis virus
Compartment
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Predicted chicken NLRC5 shows 34% amino acid sequence identity to its human counterpart. Mammalian NLRC5 blocks the CARD-CARD interaction between IPS-1 and RIG-1/MDA5 by specific binding to the CARD domains of RIG-1/ MDA5.

Literature References
PubMed ID Title Journal Year
20434986 NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways

Cui, J, Zhu, L, Xia, X, Wang, HY, Legras, X, Hong, J, Ji, J, Shen, P, Zheng, S, Chen, ZJ, Wang, RF

Cell 2010
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