Reactome | phospho-GHR [plasma membrane]

phospho-GHR [plasma membrane]

Stable Identifier

R-GGA-1168904

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

plasma membrane

Synonyms

p-5Y-GHR(19-638), A0A1D5NVR2

Locations in the PathwayBrowser

Expand all

Immune System (Gallus gallus)

- Cytokine Signaling in Immune system (Gallus gallus)
  - Growth hormone receptor signaling (Gallus gallus)
    - JAK2 phosphorylation of GHR (Gallus gallus)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Gallus gallus)
        
        phospho-GHR [plasma membrane] (Gallus gallus)
    - PTP1B binds the GH receptor complex (Gallus gallus)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Gallus gallus)
        
        phospho-GHR [plasma membrane] (Gallus gallus)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] (Gallus gallus)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Gallus gallus)
        
        phospho-GHR [plasma membrane] (Gallus gallus)
    - PTP1B dephosphorylates GHR (Gallus gallus)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] (Gallus gallus)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Gallus gallus)
        
        phospho-GHR [plasma membrane] (Gallus gallus)
    - p-STAT5A/B dissociates from the Growth Hormone receptor (Gallus gallus)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Gallus gallus)
        
        phospho-GHR [plasma membrane] (Gallus gallus)
      - Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:p-STAT5 [plasma membrane] (Gallus gallus)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
        
        Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Gallus gallus)
        
        phospho-GHR [plasma membrane] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A1D5NVR2

Gene Names

GHR

Reference Genes

ENSEMBL:ENSGALG00000014855

ENSEMBL:ENSGALG00010014614.1 GHR

Other Identifiers

408184

GO:0004896

GO:0004903

GO:0005515

GO:0005576

GO:0005615

GO:0005829

GO:0005886

GO:0006897

GO:0009897

GO:0009986

GO:0016020

GO:0016192

GO:0017046

GO:0019221

GO:0019838

GO:0019955

GO:0023052

GO:0032870

GO:0036211

GO:0036464

GO:0040018

GO:0042445

GO:0042802

GO:0042803

GO:0043226

GO:0043235

GO:0046427

GO:0048009

GO:0050731

GO:0060089

GO:0060396

GO:0070195

GT_A_87_P009190

GT_A_87_P059176

GT_A_87_P091856

GT_A_87_P091861

GT_A_87_P091871

GT_A_87_P130428

GT_Sp_Chicken_AW198548_186

Gga.4329.1.S1_at

Gga.9233.1.S1_at

Participates

as a component of

Tyrosine phosphorylated Growth Hormone Receptor:p(Y1007)-JAK2 [plasma membrane] (Gallus gallus)

Other forms of this molecule

phospho-GHR [plasma membrane]

GHR [extracellular region]

GHR [plasma membrane]

Inferred From

p-5Y-GHR(19-638) [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 332 (in Homo sapiens)

Coordinate

332

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 487 (in Homo sapiens)

Coordinate

487

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 534 (in Homo sapiens)

Coordinate

534

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 566 (in Homo sapiens)

Coordinate

566

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 627 (in Homo sapiens)

Coordinate

627

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

OpenTargets

ENSG00000112964

Ensembl

ENSGALP00010020481, ENSGALT00010035089, ENSGALG00010014614

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