Reactome | wu:fa12a02 [cytosol]

wu:fa12a02 [cytosol]

Stable Identifier

R-DRE-912578

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

ATP6V1G1, Q6PBR5

Locations in the PathwayBrowser

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Cellular responses to stimuli (Danio rerio)

- Cellular responses to stress (Danio rerio)
  - Cellular response to starvation (Danio rerio)
    - Amino acids regulate mTORC1 (Danio rerio)
      - RRAGA,B exchanges GDP for GTP (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)
      - RRAGA,B hydrolyzes GTP (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)
      - RRAGC,D exchanges GTP for GDP (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)
      - RRAGC,D hydrolyzes GTP (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)
      - mTORC1 binds RHEB:GTP (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Danio rerio)
        
        v-ATPase:Ragulator [lysosomal membrane] (Danio rerio)
        
        v-ATPase [lysosomal membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by Insulin receptor (Danio rerio)
    - Insulin receptor recycling (Danio rerio)
      - Endosome acidification (Danio rerio)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Danio rerio)
        
        V-ATPase [endosome membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)

Transport of small molecules (Danio rerio)

- Iron uptake and transport (Danio rerio)
  - Transferrin endocytosis and recycling (Danio rerio)
    - Acidification of Tf:TfR1 containing endosome (Danio rerio)
      - V-ATPase:ATP6AP1 [endosome membrane] (Danio rerio)
        
        V-ATPase [endosome membrane] (Danio rerio)
        
        ATP6V1 [cytosol] (Danio rerio)
        
        ATP6V1G dimer [cytosol] (Danio rerio)
        
        wu:fa12a02 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6PBR5

Gene Names

wu:fa12a02

Reference Genes

BioGPS Gene:335025 wu:fa12a02

ENSEMBL:ENSDARG00000022315

ENSEMBL:ENSDARG00000022315.8 wu:fa12a02

ENSEMBL:ENSDARG00000110951.1 wu:fa12a02

KEGG Gene (Danio rerio):335025 wu:fa12a02

Monarch:335025 wu:fa12a02

NCBI Gene:335025 wu:fa12a02

Reference Transcript

RefSeq:NM_199934.1 wu:fa12a02

Other Identifiers

13198792

335025

A_15_P131911

A_15_P139583

A_15_P625551

A_15_P655731

CJ001143

DRER04412

Dr.370.1.S1_at

ENSDART00000036331

ENSDART00000036331_2

GO:0005215

GO:0005773

GO:0006811

GO:0016471

GO:0043226

GO:0046961

GO:0055085

GO:0140657

GO:1902600

GT_Xhyb_NM_199934.1_297395

GT_Xhyb_XM_005165542.1_357735

JP001143

LOLS00977

MADDr01007556

NM_199934

OTTDART00000022683

Participates

as a component of

ATP6V1G dimer [cytosol] (Danio rerio)

Other forms of this molecule

wu:fa12a02 [cytosol]

Inferred From

ATP6V1G [cytosol] (Homo sapiens)

ATP6V1G1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_956228.1

ZFIN

ZDB-GENE-030131-6965

Ensembl

ENSDARP00000146438, ENSDARP00000033069, ENSDART00000191607, ENSDARG00000110951, ENSDART00000036331, ENSDARG00000022315

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