Reactome | pde1a [cytosol]

pde1a [cytosol]

Stable Identifier

R-DRE-9014912

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

activated PDE1A, E7F6Z8

Locations in the PathwayBrowser

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Hemostasis (Danio rerio)

- Platelet homeostasis (Danio rerio)
  - Nitric oxide stimulates guanylate cyclase (Danio rerio)
    - cGMP effects (Danio rerio)
      - cGMP is degraded by PDEs (Danio rerio)
        
        cGMP phosphodiesterases [cytosol] (Danio rerio)
        
        Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Danio rerio)
        
        pde1a [cytosol] (Danio rerio)

Signal Transduction (Danio rerio)

- Intracellular signaling by second messengers (Danio rerio)
  - DAG and IP3 signaling (Danio rerio)
    - CaM pathway (Danio rerio)
      - Calmodulin induced events (Danio rerio)
        
        Cam-PDE 1 activation (Danio rerio)
        
        Calmodulin activates Cam-PDE 1 (Danio rerio)
        
        activated PDE1 dimers [cytosol] (Danio rerio)
        
        activated PDE1A dimer [cytosol] (Danio rerio)
        
        pde1a [cytosol] (Danio rerio)
        
        cAMP hydrolysis by Cam-PDE 1 (Danio rerio)
        
        activated PDE1 dimers [cytosol] (Danio rerio)
        
        activated PDE1A dimer [cytosol] (Danio rerio)
        
        pde1a [cytosol] (Danio rerio)
- Signaling by GPCR (Danio rerio)
  - GPCR downstream signalling (Danio rerio)
    - G alpha (i) signalling events (Danio rerio)
      - Opioid Signalling (Danio rerio)
        
        G-protein mediated events (Danio rerio)
        
        PLC beta mediated events (Danio rerio)
        
        Ca-dependent events (Danio rerio)
        
        CaM pathway (Danio rerio)
        
        Calmodulin induced events (Danio rerio)
        
        Cam-PDE 1 activation (Danio rerio)
        
        Calmodulin activates Cam-PDE 1 (Danio rerio)
        
        activated PDE1 dimers [cytosol] (Danio rerio)
        
        activated PDE1A dimer [cytosol] (Danio rerio)
        
        pde1a [cytosol] (Danio rerio)
        
        cAMP hydrolysis by Cam-PDE 1 (Danio rerio)
        
        activated PDE1 dimers [cytosol] (Danio rerio)
        
        activated PDE1A dimer [cytosol] (Danio rerio)
        
        pde1a [cytosol] (Danio rerio)
    - G alpha (s) signalling events (Danio rerio)
      - cAMP degradation by Phosphodiesterases (Danio rerio)
        
        cAMP PDEs [cytosol] (Danio rerio)
        
        Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Danio rerio)
        
        pde1a [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:E7F6Z8

Gene Names

pde1a

Reference Genes

BioGPS Gene:564465 pde1a

ENSEMBL:ENSDARG00000060875

KEGG Gene (Danio rerio):564465 pde1a

Monarch:564465 pde1a

NCBI Gene:564465 pde1a

Reference Transcript

RefSeq:XM_005167925.3 pde1a

Other Identifiers

13269546

564465

A_15_P307411

CUST_26248_PI428451953

CUST_26249_PI428451953

DRER39511

ENSDART00000086198

ENSDART00000086198_2

ENSDART00000086202

GO:0003674

GO:0004114

GO:0007165

GO:0008081

GO:0008150

XM_687800

Participates

as a member of

Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Danio rerio)

as a component of

activated PDE1A dimer [cytosol] (Danio rerio)

Inferred From

activated PDE1A [cytosol] (Homo sapiens)

PDE1A [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005167982.1

Ensembl

ENSDARP00000080637, ENSDARG00000060875, ENSDART00000086202