Reactome | zgc:113420 [nucleoplasm]

zgc:113420 [nucleoplasm]

Stable Identifier

R-DRE-8942507

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

VRK3, Q5BLE9

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Interleukin-17 signaling (Danio rerio)
      - MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        VRK3:DUSP3 [nucleoplasm] (Danio rerio)
        
        zgc:113420 [nucleoplasm] (Danio rerio)
- Innate Immune System (Danio rerio)
  - Toll-like Receptor Cascades (Danio rerio)
    - Toll Like Receptor 10 (TLR10) Cascade (Danio rerio)
      - MyD88 cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        VRK3:DUSP3 [nucleoplasm] (Danio rerio)
        
        zgc:113420 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 2 (TLR2) Cascade (Danio rerio)
      - Toll Like Receptor TLR1:TLR2 Cascade (Danio rerio)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        VRK3:DUSP3 [nucleoplasm] (Danio rerio)
        
        zgc:113420 [nucleoplasm] (Danio rerio)
      - Toll Like Receptor TLR6:TLR2 Cascade (Danio rerio)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        VRK3:DUSP3 [nucleoplasm] (Danio rerio)
        
        zgc:113420 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 3 (TLR3) Cascade (Danio rerio)
      - MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        VRK3:DUSP3 [nucleoplasm] (Danio rerio)
        
        zgc:113420 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
      - MyD88-independent TLR4 cascade (Danio rerio)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        VRK3:DUSP3 [nucleoplasm] (Danio rerio)
        
        zgc:113420 [nucleoplasm] (Danio rerio)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        VRK3:DUSP3 [nucleoplasm] (Danio rerio)
        
        zgc:113420 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 5 (TLR5) Cascade (Danio rerio)
      - MyD88 cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        VRK3:DUSP3 [nucleoplasm] (Danio rerio)
        
        zgc:113420 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Danio rerio)
      - MyD88 dependent cascade initiated on endosome (Danio rerio)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        VRK3:DUSP3 [nucleoplasm] (Danio rerio)
        
        zgc:113420 [nucleoplasm] (Danio rerio)
    - Toll Like Receptor 9 (TLR9) Cascade (Danio rerio)
      - MyD88 dependent cascade initiated on endosome (Danio rerio)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        VRK3:DUSP3 [nucleoplasm] (Danio rerio)
        
        zgc:113420 [nucleoplasm] (Danio rerio)

Signal Transduction (Danio rerio)

- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by NTRKs (Danio rerio)
    - Signaling by NTRK1 (TRKA) (Danio rerio)
      - Nuclear Events (kinase and transcription factor activation) (Danio rerio)
        
        ERK/MAPK targets (Danio rerio)
        
        ERKs are inactivated (Danio rerio)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Danio rerio)
        
        VRK3:DUSP3 [nucleoplasm] (Danio rerio)
        
        zgc:113420 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q5BLE9

Gene Names

zgc:113420

Reference Genes

BioGPS Gene:541443 zgc:113420

ENSEMBL:ENSDARG00000036056

KEGG Gene (Danio rerio):541443 zgc:113420

Monarch:541443 zgc:113420

NCBI Gene:541443 zgc:113420

Reference Transcript

RefSeq:NM_001013568.2 zgc:113420

Participates

as a component of

VRK3:DUSP3 [nucleoplasm] (Danio rerio)

Inferred From

VRK3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001013586.1

ZFIN

ZDB-GENE-030131-246

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