Reactome | m6pr [clathrin-coated endocytic vesicle membrane]

m6pr [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-DRE-8869100

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

M6PR, Q6P032

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Danio rerio)

- Membrane Trafficking (Danio rerio)
  - Clathrin-mediated endocytosis (Danio rerio)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        m6pr [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        m6pr [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        m6pr [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        m6pr [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        m6pr [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        m6pr [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Dissociation of clathrin-associated proteins (Danio rerio)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        m6pr [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        m6pr [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        m6pr [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        m6pr [clathrin-coated endocytic vesicle membrane] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        m6pr [clathrin-coated endocytic vesicle membrane] (Danio rerio)
    - RAB5 and GAPVD1 bind AP-2 (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        m6pr [clathrin-coated endocytic vesicle membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:Q6P032

Gene Names

m6pr

Reference Genes

BioGPS Gene:406486 m6pr

ENSEMBL:ENSDARG00000018432

KEGG Gene (Danio rerio):406486 m6pr

Monarch:406486 m6pr

NCBI Gene:406486 m6pr

Reference Transcript

RefSeq:NM_213205.1 m6pr

Other Identifiers

13037652

406486

A_15_P107114

A_15_P109553

A_15_P305571

A_15_P495147

CJ000069

CUST_13057_PI428451953

CUST_13058_PI428451953

CUST_5214_PI428451958

DRER02091

DRER29307

DRER37355

Dr.11519.1.A1_at

ENSDART00000017142

ENSDART00000017142_1

ENSDART00000017142_2

GO:0003674

GO:0005537

GO:0005575

GO:0005622

GO:0005737

GO:0005768

GO:0005794

GO:0005802

GO:0006605

GO:0006622

GO:0006810

GO:0007034

GO:0008150

GO:0015031

GO:0016020

GO:0016021

GO:0019904

GO:0031410

GO:0043226

GT_Spec_NM_213205.1_232075

JP000069

LOLS02026

MADDr01001197

NM_213205

ZV700S00000446

Participates

as a member of

AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)

Other forms of this molecule

m6pr [plasma membrane]

m6pr [Golgi membrane]

m6pr [lysosomal membrane]

m6pr [transport vesicle]

m6pr [trans-Golgi network membrane]

Inferred From

M6PR [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_998370.1

Ensembl

ENSDART00000178425, ENSDART00000017142, ENSDARP00000144386, ENSDARG00000018432, ENSDARP00000018076

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