Reactome | zgc:136591 [cytosol]

zgc:136591 [cytosol]

Stable Identifier

R-DRE-8868814

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPL22L1, Q0VFW0

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        RPL22,RPL22L1 [cytosol] (Danio rerio)
        
        zgc:136591 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        RPL22,RPL22L1 [cytosol] (Danio rerio)
        
        zgc:136591 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        RPL22,RPL22L1 [cytosol] (Danio rerio)
        
        zgc:136591 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        RPL22,RPL22L1 [cytosol] (Danio rerio)
        
        zgc:136591 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        RPL22,RPL22L1 [cytosol] (Danio rerio)
        
        zgc:136591 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        RPL22,RPL22L1 [cytosol] (Danio rerio)
        
        zgc:136591 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        RPL22,RPL22L1 [cytosol] (Danio rerio)
        
        zgc:136591 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q0VFW0

Gene Names

zgc:136591

Reference Genes

BioGPS Gene:735250 zgc:136591

ENSEMBL:ENSDARG00000010244

ENSEMBL:ENSDARG00000010244.12 zgc:136591

KEGG Gene (Danio rerio):735250 zgc:136591

Monarch:735250 zgc:136591

NCBI Gene:735250 zgc:136591

Reference Transcript

RefSeq:NM_001045335.2 zgc:136591

Other Identifiers

13151496

735250

A_15_P235701

CUST_10325_PI428451953

CUST_10326_PI428451953

DRER11597

DRER36084

DRER38787

Dr.26511.1.S1_at

ENSDART00000004535_2

ENSDART00000079984

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005634

GO:0005840

GO:0006412

GO:0016071

GO:0030154

GO:0036002

GO:0043226

GO:0048856

GO:0060028

GO:0060216

GO:1905744

GO:1990904

GT_Spec_NM_001045335.2_161686

MADDr01000636

NM_001045335

XM_679722

ZV700S00004835

Participates

as a candidate of

RPL22,RPL22L1 [cytosol] (Danio rerio)

Inferred From

RPL22L1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001038800.1

ZFIN

ZDB-GENE-060804-3

Ensembl

ENSDARG00000010244, ENSDARP00000074434, ENSDART00000079984

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