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phospho-irs2b [cytosol]
Stable Identifier
R-DRE-74774
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
p-Y-IRS2, A0A0R4IKQ9
Locations in the PathwayBrowser
Expand all
Signal Transduction (Danio rerio)
MAPK family signaling cascades (Danio rerio)
MAPK1/MAPK3 signaling (Danio rerio)
RAF/MAP kinase cascade (Danio rerio)
RAS GEFs promote RAS nucleotide exchange (Danio rerio)
RAS GEFs [plasma membrane] (Danio rerio)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
Signaling by Erythropoietin (Danio rerio)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Danio rerio)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Danio rerio)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Danio rerio)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Danio rerio)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Danio rerio)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Danio rerio)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Danio rerio)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
PI3K bound to EPOR [plasma membrane] (Danio rerio)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Danio rerio)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Danio rerio)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by Insulin receptor (Danio rerio)
Insulin receptor signalling cascade (Danio rerio)
IRS activation (Danio rerio)
Dissociation of IRS-P from insulin receptor (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
Phosphorylation of IRS (Danio rerio)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
PI3K-containing complexes [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
SOS-mediated signalling (Danio rerio)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Danio rerio)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
Signal attenuation (Danio rerio)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Danio rerio)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Danio rerio)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
Signaling by NTRKs (Danio rerio)
Signaling by NTRK1 (TRKA) (Danio rerio)
PI3K/AKT activation (Danio rerio)
Active IRS recruits PI3K to the plasma membrane and activates it (Danio rerio)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Danio rerio)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
PI3K produces PIP3 and other phosphatidyl inositides (Danio rerio)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Danio rerio)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Danio rerio)
IGF1R signaling cascade (Danio rerio)
IRS-related events triggered by IGF1R (Danio rerio)
IRS-mediated signalling (Danio rerio)
PI3K Cascade (Danio rerio)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Danio rerio)
PI3K-containing complexes [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
SOS-mediated signalling (Danio rerio)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Danio rerio)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Danio rerio)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
phospho-irs2b [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:A0A0R4IKQ9
Gene Names
irs2b
Reference Genes
BioGPS Gene:572001 irs2b
CTD Gene:572001 irs2b
ENSEMBL:ENSDARG00000075282
KEGG:dre:572001 irs2b
Monarch:572001 irs2b
NCBI Gene:572001 irs2b
UCSC:A0A0R4IKQ9 irs2b
Reference Transcript
RefSeq:XM_695654.10 irs2b
Other Identifiers
13264582
572001
A_15_P320046
A_15_P368180
A_15_P429775
DRER18400
DRER41047
Dr.9217.1.A1_at
ENSDART00000110158
GO:0005158
GO:0008286
GT_Spec_XM_695654.6_167416
JP011477
LOLS11297
LOLS11523
XM_695654
Participates
as a component of
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Danio rerio)
as a member of
p-Y-IRS1,p-Y-IRS2 [cytosol] (Danio rerio)
Other forms of this molecule
irs2b [cytosol]
phospho-irs2b [plasma membrane]
Inferred From
p-Y-IRS2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_700746.4
ENSEMBL
ENSDARG00000075282
,
ENSDART00000110158
,
ENSDARP00000136042
ZFIN
ZDB-GENE-081104-462
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