Reactome | grb2a [cytosol]

grb2a [cytosol]

Stable Identifier

R-DRE-74686

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

GRB2-1, Q5RKN6

Locations in the PathwayBrowser

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Developmental Biology (Danio rerio)

- Nervous system development (Danio rerio)
  - Axon guidance (Danio rerio)
    - NCAM signaling for neurite out-growth (Danio rerio)
      - NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Danio rerio)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Danio rerio)
        
        pFAK:Grb2:Sos [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - Recruitment of Grb2 to pFAK:NCAM1 (Danio rerio)
        
        Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Danio rerio)
        
        pFAK:Grb2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - RET signaling (Danio rerio)
      - GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - p-5Y-RET complexes bind GRB2 (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)

Immune System (Danio rerio)

- Adaptive Immune System (Danio rerio)
  - Costimulation by the CD28 family (Danio rerio)
    - CD28 co-stimulation (Danio rerio)
      - CD28 dependent Vav1 pathway (Danio rerio)
        
        Activation of Cdc42 by pVav1 (Danio rerio)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Danio rerio)
        
        CD28:Grb2 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        Activation of Rac1 by pVav1 (Danio rerio)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Danio rerio)
        
        CD28:Grb2 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        Activation of Vav1 (Danio rerio)
        
        VAV1:PIP3:CD28:GRB2 [plasma membrane] (Danio rerio)
        
        CD28:Grb2 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Danio rerio)
        
        CD28:Grb2 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        Grb2 binds CD28 (Danio rerio)
        
        CD28:Grb2 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - Grb2 binds pBTLA (Danio rerio)
      - GRB2:pBTLA:HVEM [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - grb2a [cytosol] (Danio rerio)
  - Signaling by the B Cell Receptor (BCR) (Danio rerio)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Danio rerio)
      - p-6Y-SYK phosphorylates BLNK (SLP65) (Danio rerio)
        
        BLNK:GRB2:SOS1:CIN85 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
- Cytokine Signaling in Immune system (Danio rerio)
  - FLT3 Signaling (Danio rerio)
    - Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Danio rerio)
      - Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Danio rerio)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Danio rerio)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Danio rerio)
        
        Active FLT3: GRB2 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Danio rerio)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Danio rerio)
        
        Active FLT3: GRB2 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
  - Signaling by CSF3 (G-CSF) (Danio rerio)
    - p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Danio rerio)
      - CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Interleukin-2 family signaling (Danio rerio)
      - Interleukin receptor SHC signaling (Danio rerio)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        GRB2:p-Y-GAB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        GRB2:p-Y-GAB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        GRB2:p-Y-GAB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        GRB2:p-Y-GAB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        GRB2:p-Y-GAB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Danio rerio)
        
        GRB2:GAB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        GRB2:p-Y-GAB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Danio rerio)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Danio rerio)
      - Interleukin receptor SHC signaling (Danio rerio)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        GRB2:p-Y-GAB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        GRB2:p-Y-GAB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        GRB2:p-Y-GAB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        GRB2:p-Y-GAB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        GRB2:p-Y-GAB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Danio rerio)
        
        GRB2:GAB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Danio rerio)
        
        GRB2:p-Y-GAB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Danio rerio)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - Regulation of signaling by CBL (Danio rerio)
        
        CBL ubiquitinates PI3K (Danio rerio)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Danio rerio)
        
        FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
- Innate Immune System (Danio rerio)
  - DAP12 interactions (Danio rerio)
    - DAP12 signaling (Danio rerio)
      - Activation of RAC1 by VAV2/3 (Danio rerio)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Danio rerio)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - Release of p-PLCG1 (Danio rerio)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
  - Fc epsilon receptor (FCERI) signaling (Danio rerio)
    - FCERI mediated Ca+2 mobilization (Danio rerio)
      - Autophosphorylation of BTK/ITK (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - Hydrolysis of PIP2 by PLCG (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - Phosphorylation of TEC kinases by p-SYK (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - FCERI mediated MAPK activation (Danio rerio)
      - Activation of RAC1 by VAV (Danio rerio)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - Autophosphorylation of PAK (Danio rerio)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - Phosphorylation and activation of VAV (Danio rerio)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - Recruitment of PAK to the membrane by binding active RAC1 (Danio rerio)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Danio rerio)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        p-SHC1:GRB2:SOS [cytosol] (Danio rerio)
        
        GRB2-1:SOS1 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Danio rerio)
    - Regulation of actin dynamics for phagocytic cup formation (Danio rerio)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Danio rerio)
        
        Mother filament:branching complex [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - Detachment of WASP/WAVE (Danio rerio)
        
        Mother filament:branching complex [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - Src phosphorylate WASP,N-WASP (Danio rerio)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - WIP binds WASP,N-WASP, activating them (Danio rerio)
        
        CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        SH3 domain proteins [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)

Vesicle-mediated transport (Danio rerio)

- Membrane Trafficking (Danio rerio)
  - Clathrin-mediated endocytosis (Danio rerio)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - BAR domain proteins recruit dynamin (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Danio rerio)
      - CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - Cargo recognition for clathrin-mediated endocytosis (Danio rerio)
      - Epsin family proteins bind ubiquitinated cargo (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - Clathrin recruits PIK3C2A (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - Dissociation of clathrin-associated proteins (Danio rerio)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - RAB5 and GAPVD1 bind AP-2 (Danio rerio)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [clathrin-coated endocytic vesicle membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - SNX9 recruits components of the actin polymerizing machinery (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Danio rerio)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Danio rerio)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        CLASP proteins:cargo [plasma membrane] (Danio rerio)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        ubiquitinated cargo [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Danio rerio)
        
        p-Y371-CBL:GRB2 [cytosol] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Danio rerio)
        
        grb2a [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q5RKN6

Gene Names

grb2a

Reference Genes

BioGPS Gene:493609 grb2a

CTD Gene:493609 grb2a

ENSEMBL:ENSDARG00000105276

ENSEMBL:ENSDARG00000111933 grb2a

ENSEMBL:ENSDARG00000115948 grb2a

KEGG Gene (Danio rerio):493609 grb2a

Monarch:493609 grb2a

NCBI Gene:493609 grb2a

Reference Transcript

RefSeq:NM_001007769.1 grb2a

Other Identifiers

13212903

493609

A_15_P487735

CUST_15329_PI428451953

CUST_7903_PI428451958

DRER01046

DRER44539

Dr.20787.1.A1_at

Dr.20787.2.A1_a_at

ENSDART00000009214

ENSDART00000009214_1

ENSDART00000009214_2

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005768

GO:0005794

GO:0031410

GO:0043226

GT_Spec_NM_001007769.1_25831

LOLS14892

MADDr01010200

NM_001007769

OTTDART00000021972

Participates

as a component of

as an input of

as a member of

Other forms of this molecule

grb2a [plasma membrane]

Inferred From

GRB2-1 [cytosol] (Homo sapiens)

GRB2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001007770.1

Ensembl

ENSDART00000182927, ENSDART00000185100, ENSDARP00000146415, ENSDARP00000149623, ENSDARG00000105276, ENSDART00000182344, ENSDARP00000133720, ENSDART00000164114, ENSDARG00000111933, ENSDARG00000115948, ENSDARP00000151370

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