Reactome | wu:fa93h05 [cytosol]

wu:fa93h05 [cytosol]

Stable Identifier

R-DRE-72484

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

RPL6, Q567N5

Locations in the PathwayBrowser

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Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        wu:fa93h05 [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        wu:fa93h05 [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        wu:fa93h05 [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        wu:fa93h05 [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        wu:fa93h05 [cytosol] (Danio rerio)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Danio rerio)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        wu:fa93h05 [cytosol] (Danio rerio)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Danio rerio)
        
        80S ribosome [cytosol] (Danio rerio)
        
        60S ribosomal complex [cytosol] (Danio rerio)
        
        wu:fa93h05 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:Q567N5

Gene Names

wu:fa93h05

Reference Genes

BioGPS Gene:336727 wu:fa93h05

ENSEMBL:ENSDARG00000058451

ENSEMBL:ENSDARG00000058451.8 wu:fa93h05

KEGG Gene (Danio rerio):336727 wu:fa93h05

Monarch:336727 wu:fa93h05

NCBI Gene:336727 wu:fa93h05

Reference Transcript

Other Identifiers

13249873

336727

A_15_P118169

A_15_P192826

A_15_P400885

A_15_P746726

CJ014413

CUST_7526_PI428451953

DRER15616

DRER26444

Dr.284.3.S1_a_at

ENSDART00000081320_1

ENSDART00000081320_2

ENSDART00000101125

GO:0000027

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0006412

GO:0022625

GO:0031016

GO:0042254

GO:0043009

GO:0043226

GO:0048856

GO:0065003

GO:1990904

GT_Xhyb_XM_005166741.1_87351

LOLS15262

MADDr01003702

NM_001003844

Participates

as a component of

Inferred From

RPL6 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001315515.1, NP_001003844.2

ZFIN

ZDB-GENE-030131-8671

Ensembl

ENSDARP00000107457, ENSDART00000101125, ENSDARP00000091899, ENSDARG00000058451, ENSDARP00000136100, ENSDART00000171559, ENSDART00000125124

PDB

7OYA, 7OYB

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