Reactome | phospho-crfb2 [plasma membrane]

phospho-crfb2 [plasma membrane]

Stable Identifier

R-DRE-6784793-5

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

plasma membrane

Synonyms

p-Y496-IL10RA, B0UXH1

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Interleukin-10 signaling (Danio rerio)
      - IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA [plasma membrane] (Danio rerio)
        
        Homologues of p-Y496-IL10RA [plasma membrane] (Danio rerio)
        
        phospho-crfb2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA [plasma membrane] (Danio rerio)
        
        Homologues of p-Y496-IL10RA [plasma membrane] (Danio rerio)
        
        phospho-crfb2 [plasma membrane] (Danio rerio)
      - STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA [plasma membrane] (Danio rerio)
        
        Homologues of p-Y496-IL10RA [plasma membrane] (Danio rerio)
        
        phospho-crfb2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA [plasma membrane] (Danio rerio)
        
        Homologues of p-Y496-IL10RA [plasma membrane] (Danio rerio)
        
        phospho-crfb2 [plasma membrane] (Danio rerio)
      - p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA [plasma membrane] (Danio rerio)
        
        Homologues of p-Y496-IL10RA [plasma membrane] (Danio rerio)
        
        phospho-crfb2 [plasma membrane] (Danio rerio)
      - p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA [plasma membrane] (Danio rerio)
        
        Homologues of p-Y496-IL10RA [plasma membrane] (Danio rerio)
        
        phospho-crfb2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Danio rerio)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Danio rerio)
        
        p-Y-IL10RA [plasma membrane] (Danio rerio)
        
        Homologues of p-Y496-IL10RA [plasma membrane] (Danio rerio)
        
        phospho-crfb2 [plasma membrane] (Danio rerio)

External Reference Information

External Reference

UniProt:B0UXH1

Gene Names

crfb2

Reference Genes

BioGPS Gene:777653 crfb2

CTD Gene:777653 crfb2

ENSEMBL:ENSDARG00000040332

KEGG Gene (Danio rerio):777653 crfb2

Monarch:777653 crfb2

NCBI Gene:777653 crfb2

Reference Transcript

RefSeq:NM_001077626.2 crfb2

Other Identifiers

13265719

777653

A_15_P142647

CJ001325

CJ001326

CJ007639

CJ007640

CUST_9934_PI428451958

DRER31642

DRER40738

ENSDART00000090175

ENSDART00000090175_1

ENSDART00000090175_2

GO:0003674

GO:0004896

GO:0004904

GO:0005515

GO:0005575

GO:0005886

GO:0007165

GO:0008150

GO:0016020

GO:0016021

GO:0019221

GT_Xhyb_NM_001077626.1_83741

GT_Xhyb_XM_005167960.1_36781

JP001325

JP001326

JP008037

JP008038

NM_001077626

Participant Of

hasMember

Homologues of p-Y496-IL10RA [plasma membrane]

Other forms of this molecule

phospho-crfb2 [plasma membrane]

crfb2 [extracellular region]

crfb2 [plasma membrane]

phospho-crfb2 [plasma membrane]

crfb2 [plasma membrane]

phospho-crfb2 [plasma membrane]

crfb2 [plasma membrane]

Inferred From

p-Y496-IL10RA [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 496 (in Homo sapiens)

Coordinate

496

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001071094.2

Ensembl

ENSDARP00000120706, ENSDART00000131957, ENSDARG00000040332

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