Reactome | zgc:92126 [nucleoplasm]

zgc:92126 [nucleoplasm]

Stable Identifier

R-DRE-65912

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

GTF2H1, Q66I03

Locations in the PathwayBrowser

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DNA Repair (Danio rerio)

- Nucleotide Excision Repair (Danio rerio)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Danio rerio)
    - Dual Incision in GG-NER (Danio rerio)
      - 5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Danio rerio)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Danio rerio)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Danio rerio)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
    - Formation of Incision Complex in GG-NER (Danio rerio)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Danio rerio)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Danio rerio)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Danio rerio)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Danio rerio)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
      - CHD1L is recruited to GG-NER site (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
      - ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
      - TFIIH binds GG-NER site to form a verification complex (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Danio rerio)
    - Dual incision in TC-NER (Danio rerio)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Danio rerio)
        
        TC-NER incision complex [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Danio rerio)
        
        TC-NER incision complex [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
        
        TC-NER pre-incision complex [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
    - Formation of TC-NER Pre-Incision Complex (Danio rerio)
      - UVSSA:USP7 deubiquitinates ERCC6 (Danio rerio)
        
        TC-NER pre-incision complex [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        zgc:92126 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q66I03

Gene Names

zgc:92126

Reference Genes

BioGPS Gene:447857 zgc:92126

ENSEMBL:ENSDARG00000026701

ENSEMBL:ENSDARG00000026701.6 zgc:92126

KEGG Gene (Danio rerio):447857 zgc:92126

Monarch:447857 zgc:92126

NCBI Gene:447857 zgc:92126

Reference Transcript

RefSeq:NM_001004596.1 zgc:92126

Other Identifiers

13159268

13159293

447857

A_15_P103529

A_15_P258981

A_15_P719911

CUST_3004_PI428451958

DRER04033

DRER38789

DRER49909

Dr.16674.1.S1_at

ENSDART00000032390

ENSDART00000032390_2

GO:0000439

GO:0005634

GO:0005654

GO:0005675

GO:0006281

GO:0006289

GO:0006351

GO:0006360

GO:0006366

GO:0043226

GT_Spec_NM_001004596.1_294395

LOLS08813

MADDr01001674

NM_001004596

ZV700S00002192

Participates

as a component of

Inferred From

GTF2H1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001004596.1

ZFIN

ZDB-GENE-040912-164

Ensembl

ENSDARP00000038901, ENSDART00000032390, ENSDARG00000026701

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