Reactome | si:dkey-12h9.4 [nucleoplasm]

si:dkey-12h9.4 [nucleoplasm]

Stable Identifier

R-DRE-5688446

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

GTF2H5, Q5SNQ6

Locations in the PathwayBrowser

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DNA Repair (Danio rerio)

- Nucleotide Excision Repair (Danio rerio)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Danio rerio)
    - Dual Incision in GG-NER (Danio rerio)
      - 5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Danio rerio)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Danio rerio)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Danio rerio)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
    - Formation of Incision Complex in GG-NER (Danio rerio)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Danio rerio)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Danio rerio)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Danio rerio)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Danio rerio)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
      - CHD1L is recruited to GG-NER site (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
      - ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Danio rerio)
        
        TFIIH Core [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
      - TFIIH binds GG-NER site to form a verification complex (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Danio rerio)
    - Dual incision in TC-NER (Danio rerio)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Danio rerio)
        
        TC-NER incision complex [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Danio rerio)
        
        TC-NER incision complex [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
        
        TC-NER pre-incision complex [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Danio rerio)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
    - Formation of TC-NER Pre-Incision Complex (Danio rerio)
      - UVSSA:USP7 deubiquitinates ERCC6 (Danio rerio)
        
        TC-NER pre-incision complex [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Danio rerio)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Danio rerio)
        
        TFIIH [nucleoplasm] (Danio rerio)
        
        si:dkey-12h9.4 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q5SNQ6

Gene Names

si:dkey-12h9.4

Reference Genes

BioGPS Gene:751713 si:dkey-12h9.4

ENSEMBL:ENSDARG00000056099

ENSEMBL:ENSDARG00000056099.8 si:dkey-12h9.4

ENSEMBL:ENSDARG00000114297.1 si:dkey-12h9.4

KEGG Gene (Danio rerio):751713 si:dkey-12h9.4

Monarch:751713 si:dkey-12h9.4

NCBI Gene:751713 si:dkey-12h9.4

Reference Transcript

Other Identifiers

13102945

13283124

13284324

751713

A_15_P108111

A_15_P108571

A_15_P410430

A_15_P659821

BC122292

CJ004301

CUST_1111_PI428451958

CUST_17428_PI428451953

DRER11179

DRER19809

DRER40365

DRER49843

DRER50066

Dr.14153.1.S1_at

ENSDART00000078535

ENSDART00000078535_1

ENSDART00000078535_2

GO:0000439

GO:0005634

GO:0005654

GO:0005675

GO:0006281

GO:0006289

GO:0006294

GO:0006351

GO:0006366

GO:0006367

GO:0006974

GO:0043226

GO:0065003

GT_Spec_XM_005160597.1_172605

GT_Xhyb_NM_001134362.2_385045

GT_Xhyb_NM_001243148.1_385035

GT_Xhyb_XM_005160598.1_172586

JP004700

LOLS07263

MADDr01005410

OTTDART00000005886

OTTDART00000005887

Participates

as a component of

Inferred From

GTF2H5 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001289673.1, NP_001127834.2, NP_001230077.1, XP_021324196.1

ZFIN

ZDB-GENE-041001-144

Ensembl

ENSDART00000151874, ENSDARP00000072996, ENSDARG00000056099, ENSDARG00000114297, ENSDART00000078535, ENSDARP00000119850, ENSDARP00000155117, ENSDART00000183586, ENSDART00000141626, ENSDARP00000126549

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