Reactome | tnfsf10l4 [extracellular region]

tnfsf10l4 [extracellular region]

Stable Identifier

R-DRE-5676547-3

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

extracellular region

Synonyms

sTNFSF11, Q0PKX8

Locations in the PathwayBrowser

Expand all

Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - TNFR2 non-canonical NF-kB pathway (Danio rerio)
    - K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Danio rerio)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Danio rerio)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Danio rerio)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        sRANKL trimer [extracellular region] (Danio rerio)
        
        Homologues of sTNFSF11 [extracellular region] (Danio rerio)
        
        tnfsf10l4 [extracellular region] (Danio rerio)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Danio rerio)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Danio rerio)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        sRANKL trimer [extracellular region] (Danio rerio)
        
        Homologues of sTNFSF11 [extracellular region] (Danio rerio)
        
        tnfsf10l4 [extracellular region] (Danio rerio)
    - Protesomal degradation of K48polyUb-TRAF3 (Danio rerio)
      - TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Danio rerio)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        sRANKL trimer [extracellular region] (Danio rerio)
        
        Homologues of sTNFSF11 [extracellular region] (Danio rerio)
        
        tnfsf10l4 [extracellular region] (Danio rerio)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Danio rerio)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Danio rerio)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        sRANKL trimer [extracellular region] (Danio rerio)
        
        Homologues of sTNFSF11 [extracellular region] (Danio rerio)
        
        tnfsf10l4 [extracellular region] (Danio rerio)
    - TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Danio rerio)
      - 2xRANK binds RANKL,sRANKL trimer:RANK (Danio rerio)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        sRANKL trimer [extracellular region] (Danio rerio)
        
        Homologues of sTNFSF11 [extracellular region] (Danio rerio)
        
        tnfsf10l4 [extracellular region] (Danio rerio)
        
        RANK:RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        sRANKL trimer [extracellular region] (Danio rerio)
        
        Homologues of sTNFSF11 [extracellular region] (Danio rerio)
        
        tnfsf10l4 [extracellular region] (Danio rerio)
      - RANKL,sRANKL trimer binds RANK (Danio rerio)
        
        RANK:RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        sRANKL trimer [extracellular region] (Danio rerio)
        
        Homologues of sTNFSF11 [extracellular region] (Danio rerio)
        
        tnfsf10l4 [extracellular region] (Danio rerio)
        
        RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        sRANKL trimer [extracellular region] (Danio rerio)
        
        Homologues of sTNFSF11 [extracellular region] (Danio rerio)
        
        tnfsf10l4 [extracellular region] (Danio rerio)
      - TRAFs bind RANK:RANKL (Danio rerio)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        sRANKL trimer [extracellular region] (Danio rerio)
        
        Homologues of sTNFSF11 [extracellular region] (Danio rerio)
        
        tnfsf10l4 [extracellular region] (Danio rerio)
        
        3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Danio rerio)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        sRANKL trimer [extracellular region] (Danio rerio)
        
        Homologues of sTNFSF11 [extracellular region] (Danio rerio)
        
        tnfsf10l4 [extracellular region] (Danio rerio)
    - TNFs bind their physiological receptors (Danio rerio)
      - TNFSF11 binds TNFRSF11A, B (Danio rerio)
        
        RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        sRANKL trimer [extracellular region] (Danio rerio)
        
        Homologues of sTNFSF11 [extracellular region] (Danio rerio)
        
        tnfsf10l4 [extracellular region] (Danio rerio)
        
        TNFSF11,sTNFSF11 trimer:3xTNFRSF11B [plasma membrane] (Danio rerio)
        
        RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        sRANKL trimer [extracellular region] (Danio rerio)
        
        Homologues of sTNFSF11 [extracellular region] (Danio rerio)
        
        tnfsf10l4 [extracellular region] (Danio rerio)
    - TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Danio rerio)
      - Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Danio rerio)
        
        3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Danio rerio)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        sRANKL trimer [extracellular region] (Danio rerio)
        
        Homologues of sTNFSF11 [extracellular region] (Danio rerio)
        
        tnfsf10l4 [extracellular region] (Danio rerio)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Danio rerio)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Danio rerio)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        sRANKL trimer [extracellular region] (Danio rerio)
        
        Homologues of sTNFSF11 [extracellular region] (Danio rerio)
        
        tnfsf10l4 [extracellular region] (Danio rerio)
    - cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Danio rerio)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Danio rerio)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Danio rerio)
        
        3xRANK:RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        RANKL,sRANKL trimer [plasma membrane] (Danio rerio)
        
        sRANKL trimer [extracellular region] (Danio rerio)
        
        Homologues of sTNFSF11 [extracellular region] (Danio rerio)
        
        tnfsf10l4 [extracellular region] (Danio rerio)

External Reference Information

External Reference

UniProt:Q0PKX8

Gene Names

tnfsf10l4

Reference Genes

BioGPS Gene:503595 tnfsf10l4

CTD Gene:503595 tnfsf10l4

ENSEMBL:ENSDARG00000058068

ENSEMBL:ENSDARG00000111545 tnfsf10l4

Monarch:503595 tnfsf10l4

NCBI Gene:503595 tnfsf10l4

Reference Transcript

RefSeq:XM_005165144.2 tnfsf10l4

Other Identifiers

13194084

503595

CJ003369

CJ003370

CJ003427

CJ003428

CJ007798

CJ007799

CJ007800

CJ011101

CJ011102

CJ011103

CUST_8278_PI428451958

DRER11824

Dr.17236.1.A1_at

Dr.17236.2.S1_at

ENSDART00000080877

ENSDART00000080877_1

ENSDART00000080877_2

GO:0002376

GO:0003674

GO:0005164

GO:0005515

GO:0005575

GO:0006955

GO:0008150

GO:0016020

GO:0016021

GT_Xhyb_NM_001013283.1_297125

GT_Xhyb_XM_005165144.1_300445

JP003768

JP003769

JP003826

JP003827

JP008196

JP008197

JP008198

MADDr01010660

NM_001013283

OTTDART00000019114

XM_684902

Participates

as a member of

Homologues of sTNFSF11 [extracellular region] (Danio rerio)

Other forms of this molecule

tnfsf10l4 [plasma membrane]

Inferred From

sTNFSF11 [extracellular region] (Homo sapiens)

Cross References

RefSeq

XP_005165201.1

Ensembl

ENSDARG00000111545, ENSDART00000080877, ENSDARP00000075321, ENSDARG00000058068, ENSDARP00000149652, ENSDART00000180292

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