Reactome | Ghost homologue of HGF(32-494) [extracellular region]

Ghost homologue of HGF(32-494) [extracellular region]

Stable Identifier

R-DRE-56497

Type

Genes and Transcripts [GenomeEncodedEntity]

Species

Danio rerio

Compartment

extracellular region

Locations in the PathwayBrowser

Expand all

Signal Transduction (Danio rerio)

- MAPK family signaling cascades (Danio rerio)
  - MAPK1/MAPK3 signaling (Danio rerio)
    - RAF/MAP kinase cascade (Danio rerio)
      - RAS GEFs promote RAS nucleotide exchange (Danio rerio)
        
        RAS GEFs [plasma membrane] (Danio rerio)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Danio rerio)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Danio rerio)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Danio rerio)
        
        HGF dimer [extracellular region] (Danio rerio)
        
        Ghost homologue of HGF(32-494) [extracellular region] (Danio rerio)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Danio rerio)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Danio rerio)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Danio rerio)
        
        HGF dimer [extracellular region] (Danio rerio)
        
        Ghost homologue of HGF(32-494) [extracellular region] (Danio rerio)
- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by MET (Danio rerio)
    - MET activates RAS signaling (Danio rerio)
      - RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Danio rerio)
        
        HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Danio rerio)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Danio rerio)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Danio rerio)
        
        HGF dimer [extracellular region] (Danio rerio)
        
        Ghost homologue of HGF(32-494) [extracellular region] (Danio rerio)
      - RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Danio rerio)
        
        HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Danio rerio)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Danio rerio)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Danio rerio)
        
        HGF dimer [extracellular region] (Danio rerio)
        
        Ghost homologue of HGF(32-494) [extracellular region] (Danio rerio)
    - Negative regulation of MET activity (Danio rerio)
      - CBL monoubiquitinates activated MET (Danio rerio)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Danio rerio)
        
        HGF:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Danio rerio)
        
        HGF dimer:MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Danio rerio)
        
        HGF dimer [extracellular region] (Danio rerio)
        
        Ghost homologue of HGF(32-494) [extracellular region] (Danio rerio)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Danio rerio)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Danio rerio)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Danio rerio)
        
        HGF dimer [extracellular region] (Danio rerio)
        
        Ghost homologue of HGF(32-494) [extracellular region] (Danio rerio)
      - MET phosphorylates CBL (Danio rerio)
        
        HGF:p-4Y-MET dimer:GRB2:CBL [plasma membrane] (Danio rerio)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Danio rerio)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Danio rerio)
        
        HGF dimer [extracellular region] (Danio rerio)
        
        Ghost homologue of HGF(32-494) [extracellular region] (Danio rerio)
        
        HGF:p-4Y-MET dimer:GRB2:p-Y-CBL [plasma membrane] (Danio rerio)
        
        HGF:p-Y1234,Y1235,Y1349,Y1356-MET dimer [plasma membrane] (Danio rerio)
        
        HGF dimer:p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (Danio rerio)
        
        HGF dimer [extracellular region] (Danio rerio)
        
        Ghost homologue of HGF(32-494) [extracellular region] (Danio rerio)

Participates

as a component of

HGF dimer [extracellular region] (Danio rerio)

Inferred From

HGF(32-494) [extracellular region] (Homo sapiens)