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POLB [nucleoplasm]
Stable Identifier
R-DRE-53845
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
nucleoplasm
Synonyms
Q6DRD3
Locations in the PathwayBrowser
Expand all
DNA Repair (Danio rerio)
Base Excision Repair (Danio rerio)
Resolution of Abasic Sites (AP sites) (Danio rerio)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (Danio rerio)
LIG3 ligates NEIL1,NEIL2-generated single strand break (Danio rerio)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
LIG3:XRCC1 and PNKP bind NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA (Danio rerio)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Danio rerio)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
NEIL1,NEIL2 recruits POLB to incised AP site (Danio rerio)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
PNKP hydrolyzes the terminal 3'Pi at the NEIL1,NEIL2-generated single strand break (SSB) (Danio rerio)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Danio rerio)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) (Danio rerio)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution (Danio rerio)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Danio rerio)
PCNA-Dependent Long Patch Base Excision Repair (Danio rerio)
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Danio rerio)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB-Dependent Long Patch Base Excision Repair (Danio rerio)
LIG1 binds POLB at long-patch BER site (Danio rerio)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Danio rerio)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
LIG1 bound to POLB ligates SSB (Danio rerio)
LIG1:POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Danio rerio)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
LIG1:POLB:dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB (Danio rerio)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Danio rerio)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Danio rerio)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB-mediated DNA strand displacement synthesis (Danio rerio)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
Recruitment of POLB to oxidatively damaged AP site (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
Resolution of AP sites via the single-nucleotide replacement pathway (Danio rerio)
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (Danio rerio)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB:SSB-gap-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
Recruitment of POLB to the AP site (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
LIG3-mediated DNA ligation via the single-nucleotide replacement pathway (Danio rerio)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
Recruitment of LIG3:XRCC1 complex to the site of repair by POLB (Danio rerio)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Danio rerio)
POLB:SSB-gap-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB:SSB-gap-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
Resynthesis of excised residue by POLB (Danio rerio)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Danio rerio)
POLB:SSB-gap-dsDNA [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
Metabolism of proteins (Danio rerio)
Post-translational protein modification (Danio rerio)
Deubiquitination (Danio rerio)
Ub-specific processing proteases (Danio rerio)
USP47 deubiquitinates POLB (Danio rerio)
USP47:POLB [nucleoplasm] (Danio rerio)
POLB [nucleoplasm] (Danio rerio)
External Reference Information
External Reference
UniProt:Q6DRD3
Reference Genes
ENSEMBL:ENSDARG00000003749
Participates
as a component of
USP47:POLB [nucleoplasm] (Danio rerio)
LIG3:XRCC1:POLB:dsDNA [nucleoplasm] (Danio rerio)
LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm] (Danio rerio)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Danio rerio)
POLB:SSB-gap-dsDNA [nucleoplasm] (Danio rerio)
LIG1:POLB:dsDNA [nucleoplasm] (Danio rerio)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Danio rerio)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Danio rerio)
PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Danio rerio)
POLB:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Danio rerio)
FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Danio rerio)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Danio rerio)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Danio rerio)
NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] (Danio rerio)
NEIL1,NEIL2:POLB:SSB(3'Pi)-gap-dsDNA [nucleoplasm] (Danio rerio)
NEIL1,NEIL2:POLB:LIG3:XRCC1:PNKP:SSB-gap-dsDNA [nucleoplasm] (Danio rerio)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:dsDNA [nucleoplasm] (Danio rerio)
NEIL1,NEIL2:PNKP:POLB:LIG3:XRCC1:SSB-dsDNA [nucleoplasm] (Danio rerio)
as an input of
Recruitment of POLB to the AP site (Danio rerio)
Recruitment of POLB to oxidatively damaged AP site (Danio rerio)
NEIL1,NEIL2 recruits POLB to incised AP site (Danio rerio)
as an output of
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Danio rerio)
Other forms of this molecule
PolyUb-POLB [nucleoplasm]
Inferred From
POLB [nucleoplasm]
(Homo sapiens)
Cross References
ZFIN
ZDB-GENE-040830-1
PRO
Q6DRD3
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