Reactome | CDK9 [nucleoplasm]

CDK9 [nucleoplasm]

Stable Identifier

R-DRE-51801

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

Q7SXE8

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Danio rerio)

- RNA Polymerase II Transcription (Danio rerio)
  - Generic Transcription Pathway (Danio rerio)
    - Transcriptional Regulation by TP53 (Danio rerio)
      - TP53 Regulates Transcription of DNA Repair Genes (Danio rerio)
        
        CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Danio rerio)
        
        CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Danio rerio)
        
        CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Danio rerio)
        
        CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Danio rerio)
        
        P-TEFb complex [nucleoplasm] (Danio rerio)
        
        CDK9 [nucleoplasm] (Danio rerio)
        
        CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Danio rerio)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Danio rerio)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Danio rerio)
        
        P-TEFb complex [nucleoplasm] (Danio rerio)
        
        CDK9 [nucleoplasm] (Danio rerio)
  - RNA Polymerase II Pre-transcription Events (Danio rerio)
    - Formation of P-TEFb complex (Danio rerio)
      - CDK9 [nucleoplasm] (Danio rerio)
      - P-TEFb complex [nucleoplasm] (Danio rerio)
        
        CDK9 [nucleoplasm] (Danio rerio)
  - RNA polymerase II transcribes snRNA genes (Danio rerio)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Danio rerio)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Danio rerio)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Danio rerio)
        
        P-TEFb complex [nucleoplasm] (Danio rerio)
        
        CDK9 [nucleoplasm] (Danio rerio)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Danio rerio)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Danio rerio)
        
        P-TEFb complex [nucleoplasm] (Danio rerio)
        
        CDK9 [nucleoplasm] (Danio rerio)
    - General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Danio rerio)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Danio rerio)
        
        P-TEFb complex [nucleoplasm] (Danio rerio)
        
        CDK9 [nucleoplasm] (Danio rerio)
      - P-TEFb complex [nucleoplasm] (Danio rerio)
        
        CDK9 [nucleoplasm] (Danio rerio)
    - Integrator complex processes the 3' end of snRNA (Danio rerio)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Danio rerio)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Danio rerio)
        
        P-TEFb complex [nucleoplasm] (Danio rerio)
        
        CDK9 [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Danio rerio)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Danio rerio)
        
        P-TEFb complex [nucleoplasm] (Danio rerio)
        
        CDK9 [nucleoplasm] (Danio rerio)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Danio rerio)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Danio rerio)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Danio rerio)
        
        P-TEFb complex [nucleoplasm] (Danio rerio)
        
        CDK9 [nucleoplasm] (Danio rerio)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Danio rerio)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Danio rerio)
        
        P-TEFb complex [nucleoplasm] (Danio rerio)
        
        CDK9 [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q7SXE8

Reference Genes

BioGPS Gene:321602

ENSEMBL:ENSDARG00000044811

KEGG:dre:321602

Monarch:321602

NCBI Entrez Gene:321602

UCSC:Q7SXE8

Reference Transcript

RefSeq:NM_212591.2

Other Identifiers

13107875

321602

A_15_P116748

A_15_P261056

CJ013501

DRER09348

Dr.26326.1.S1_at

ENSDART00000065859

ENSDART00000065859_1

ENSDART00000065859_2

GO:0003824

GO:0004672

GO:0005524

GO:0006468

GO:0016740

GO:0140096

LOLS05942

MADDr01007172

OTTDART00000026475

Participates

as an input of

Formation of P-TEFb complex (Danio rerio)

as a component of

P-TEFb complex [nucleoplasm] (Danio rerio)

Inferred From

CDK9 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_997756.1

ENSEMBL

ENSDARG00000044811, ENSDARP00000134607, ENSDART00000166287

ZFIN

ZDB-GENE-030131-321